Background Artemisinin (ART) is an efficacious and safe anti-malarial drugs but has low oral
bioavailability and auto-induction profiles during multiple dosing. The pharmacokinetic …

Ethnopharmacological relevance The chemical matrix of the herb Artemisia annua L.(A.
annua), from which artemisinin (QHS) is isolated, can enhance both the bioavailability and …

Artemisinin has been used effectively in malaria treatment. With the emerging resistance to
malaria, the optimum and judicial use of the drug has become important. The drug …

Artemether-lumefantrine is an artemisinin-based combination therapy for the treatment of
malaria, which are primarily metabolized by cytochrome P450 3A4. Therapeutic difference …

Aims The study aimed to identify the specific human cytochrome P450 (CYP450) enzymes
involved in the metabolism of artemisinin. Methods Microsomes from human B …

The study aim was to assess the inductive properties of artemisinin antimalarials using
mephenytoin as a probe for CYP2B6 and CYP2C19 enzymatic activity. The population …

Artemisinin‐hydroxychloroquine sulfate tablets (AH) are relatively inexpensive and a novel
combination therapy for the treatment of all forms of malaria, especially aminoquinine drug …

Cytochrome P450 enzyme system is the most important contributor to oxidative metabolism
of drugs. Modification, and more specifically inhibition, of this system is an important …

The traditional antimalarial herb Artemisia annua L., from which artemisinin is isolated, is
widely used in endemic regions. It has been suggested that artemisinin activity can be …

Background Artemisinin (a sesquiterpene lactone endoperoxide) has become important in
multi‐drug treatment of malaria. There is evidence that artemisinin induces drug metabolism …