A neutrophil activation signature predicts critical illness and mortality in COVID-19
Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-
19, but the mechanisms involved remain poorly understood. We carried out proteomic …
19, but the mechanisms involved remain poorly understood. We carried out proteomic …
Longitudinal characterization of circulating neutrophils uncovers phenotypes associated with severity in hospitalized COVID-19 patients
Mechanisms of neutrophil involvement in severe coronavirus disease 2019 (COVID-19)
remain incompletely understood. Here, we collect longitudinal blood samples from 306 …
remain incompletely understood. Here, we collect longitudinal blood samples from 306 …
Neutrophils and COVID-19: active participants and rational therapeutic targets
J Hazeldine, JM Lord - Frontiers in immunology, 2021 - frontiersin.org
Whilst the majority of individuals infected with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19, experience mild to …
coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19, experience mild to …
Longitudinal whole blood transcriptomic analysis characterizes neutrophil activation and interferon signaling in moderate and severe COVID-19
C Prebensen, Y Lefol, PL Myhre, T Lüders… - Scientific reports, 2023 - nature.com
A maladaptive inflammatory response has been implicated in the pathogenesis of severe
COVID-19. This study aimed to characterize the temporal dynamics of this response and …
COVID-19. This study aimed to characterize the temporal dynamics of this response and …
[HTML][HTML] Circulating activated neutrophils in COVID-19: An independent predictor for mechanical ventilation and death
D Dennison, M Al Khabori, S Al Mamari… - International Journal of …, 2021 - Elsevier
Objectives Critical illness in COVID-19 is attributed to an exaggerated host immune
response. Since neutrophils are the major component of innate immunity, we hypothesize …
response. Since neutrophils are the major component of innate immunity, we hypothesize …
Increased peripheral blood neutrophil activation phenotypes and neutrophil extracellular trap formation in critically ill coronavirus disease 2019 (COVID-19) patients: a …
Background Increased inflammation has been well defined in coronavirus disease 2019
(COVID-19), while definitive pathways driving severe forms of this disease remain uncertain …
(COVID-19), while definitive pathways driving severe forms of this disease remain uncertain …
Neutrophils in COVID-19
N Reusch, E De Domenico, L Bonaguro… - Frontiers in …, 2021 - frontiersin.org
Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …
neutrophils play an important role in the pathophysiology, particularly in those with severe …
Neutrophils and neutrophil extracellular traps drive necroinflammation in COVID-19
The COVID-19 pandemic is progressing worldwide with an alarming death toll. There is an
urgent need for novel therapeutic strategies to combat potentially fatal complications …
urgent need for novel therapeutic strategies to combat potentially fatal complications …
Transcriptional profiling of leukocytes in critically ill COVID19 patients: implications for interferon response and coagulation
SE Gill, CC Dos Santos, DB O'Gorman… - Intensive care medicine …, 2020 - Springer
Background COVID19 is caused by the SARS-CoV-2 virus and has been associated with
severe inflammation leading to organ dysfunction and mortality. Our aim was to profile the …
severe inflammation leading to organ dysfunction and mortality. Our aim was to profile the …
Monocyte-driven atypical cytokine storm and aberrant neutrophil activation as key mediators of COVID-19 disease severity
L Vanderbeke, P Van Mol, Y Van Herck… - Nature …, 2021 - nature.com
Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the
triggering of an aberrant host immune response, more so than on direct virus-induced …
triggering of an aberrant host immune response, more so than on direct virus-induced …