Pet-1 switches transcriptional targets postnatally to regulate maturation of serotonin neuron excitability
SC Wyler, WC Spencer, NH Green… - Journal of …, 2016 - Soc Neuroscience
Newborn neurons enter an extended maturation stage, during which they acquire excitability
characteristics crucial for development of presynaptic and postsynaptic connectivity. In …
characteristics crucial for development of presynaptic and postsynaptic connectivity. In …
Regulatory mechanisms controlling maturation of serotonin neuron identity and function
WC Spencer, ES Deneris - Frontiers in cellular neuroscience, 2017 - frontiersin.org
The brain serotonin (5-hydroxytryptamine; 5-HT) system has been extensively studied for its
role in normal physiology and behavior, as well as, neuropsychiatric disorders. The broad …
role in normal physiology and behavior, as well as, neuropsychiatric disorders. The broad …
A differentially autoregulated Pet-1 enhancer region is a critical target of the transcriptional cascade that governs serotonin neuron development
MM Scott, KC Krueger, ES Deneris - Journal of Neuroscience, 2005 - Soc Neuroscience
The Pet-1 [pheochromocytoma 12 ETS (E26 transformation-specific)] gene plays a critical
role in the development of serotonin (5-HT)-modulated behaviors via its control of embryonic …
role in the development of serotonin (5-HT)-modulated behaviors via its control of embryonic …
Pet-1 is required across different stages of life to regulate serotonergic function
C Liu, T Maejima, SC Wyler, G Casadesus… - Nature …, 2010 - nature.com
Transcriptional cascades are required for the specification of serotonin (5-HT) neurons and
behaviors modulated by 5-HT. Several cascade factors are expressed throughout the …
behaviors modulated by 5-HT. Several cascade factors are expressed throughout the …
[HTML][HTML] Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior
TJ Hendricks, DV Fyodorov, LJ Wegman, NB Lelutiu… - Neuron, 2003 - cell.com
Abstract The central serotonin (5-HT) neurotransmitter system is an important modulator of
diverse physiological processes and behaviors; however, the transcriptional mechanisms …
diverse physiological processes and behaviors; however, the transcriptional mechanisms …
The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes
T Hendricks, N Francis, D Fyodorov… - Journal of …, 1999 - Soc Neuroscience
Serotonin (5-HT) plays a crucial neuromodulatory role in numerous physiological and
behavioral functions, and dysfunction of the serotonergic system has been implicated in …
behavioral functions, and dysfunction of the serotonergic system has been implicated in …
Serotonergic transcription of human FEV reveals direct GATA factor interactions and fate of Pet-1-deficient serotonin neuron precursors
KC Krueger, ES Deneris - Journal of Neuroscience, 2008 - Soc Neuroscience
Altered expression of the human FEV (fifth Ewing variant) ETS transcription factor gene
impacts the level of CNS serotonin (5-HT) neuron gene expression and maternal nurturing …
impacts the level of CNS serotonin (5-HT) neuron gene expression and maternal nurturing …
Molecular genetics of mouse serotonin neurons across the lifespan
ES Deneris - Neuroscience, 2011 - Elsevier
New molecular genetics approaches have been developed over the past several years to
study brain serotonin (5-HT) neuron development and the roles of 5-HT neurons in behavior …
study brain serotonin (5-HT) neuron development and the roles of 5-HT neurons in behavior …
Region‐specific regulation of 5‐HT1A receptor expression by Pet‐1‐dependent mechanisms in vivo
KX Jacobsen, M Czesak, M Deria… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 116, 1066–1076. Abstract Serotonin (5‐hydroxytryptamine, 5‐HT)
neurotransmission is negatively regulated by 5‐HT1A autoreceptors on raphe neurons, and …
neurotransmission is negatively regulated by 5‐HT1A autoreceptors on raphe neurons, and …
Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b
A Bosco, C Bureau, P Affaticati, P Gaspar… - …, 2013 - journals.biologists.com
Serotonin is a monoamine neurotransmitter that is involved in numerous physiological
functions and its dysregulation is implicated in various psychiatric diseases. In all non …
functions and its dysregulation is implicated in various psychiatric diseases. In all non …