5-aza-2ʹ-Deoxycytidine, a DNA methyltransferase inhibitor, facilitates the inorganic phosphorus-induced mineralization of vascular smooth muscle cells

T Azechi, F Sato, R Sudo, H Wachi - Journal of atherosclerosis and …, 2014 - jstage.jst.go.jp
Aim: Vascular calcification, an independent risk factor for cardiovascular disease in patients
with chronic kidney disease (CKD), refers to the mineralization of vascular smooth muscle …

Roles of histone acetylation modifiers and other epigenetic regulators in vascular calcification

DH Kwon, J Ryu, YK Kim, H Kook - International journal of molecular …, 2020 - mdpi.com
Vascular calcification (VC) is characterized by calcium deposition inside arteries and is
closely associated with the morbidity and mortality of atherosclerosis, chronic kidney …

Trichostatin A, an HDAC class I/II inhibitor, promotes Pi-induced vascular calcification via up-regulation of the expression of alkaline phosphatase

T Azechi, D Kanehira, T Kobayashi, R Sudo… - … of atherosclerosis and …, 2013 - jstage.jst.go.jp
Aim: Vascular calcification, a major complication of chronic kidney disease (CKD), refers to
the mineralization of vascular smooth muscle cells (VSMCs), resulting from a phenotypic …

High‐phosphate‐induced calcification is related to SM22α promoter methylation in vascular smooth muscle cells

AM De Oca, JA Madueno… - Journal of Bone and …, 2010 - academic.oup.com
Hyperphosphatemia is closely related to vascular calcification in patients with chronic kidney
disease. Vascular smooth muscle cells (VSMCs) exposed to high phosphate concentrations …

[HTML][HTML] Role of cytosolic serine hydroxymethyl transferase 1 (SHMT1) in phosphate-induced vascular smooth muscle cell calcification

B Boehme, N Schelski, M Makridakis, L Henze… - Kidney and Blood …, 2018 - karger.com
Background/Aims: Hyperphosphatemia promotes medial vascular calcification, at least
partly, by induction of osteo-/chondrogenic transdifferentiation of vascular smooth muscle …

Azelnidipine inhibits Msx2-dependent osteogenic differentiation and matrix mineralization of vascular smooth muscle cells

T Shimizu, T Tanaka, T Iso, K Kawai-Kowase… - International Heart …, 2012 - jstage.jst.go.jp
Vascular calcification is an active and regulated process that is similar to bone formation.
While calcium channel blockers (CCBs) have been shown to improve outcomes in …

Phosphate regulation of vascular smooth muscle cell calcification

S Jono, MD McKee, CE Murry, A Shioi… - Circulation …, 2000 - Am Heart Assoc
Vascular calcification is a common finding in atherosclerosis and a serious problem in
diabetic and uremic patients. Because of the correlation of hyperphosphatemia and vascular …

Pharmacological induction of ferritin prevents osteoblastic transformation of smooth muscle cells

G Becs, A Zarjou, A Agarwal, KÉ Kovács… - Journal of Cellular …, 2016 - Wiley Online Library
Vascular calcification is a frequent complication of atherosclerosis, diabetes and chronic
kidney disease. In the latter group of patients, calcification is commonly seen in tunica media …

[HTML][HTML] Vascular calcification in chronic kidney disease is induced by bone morphogenetic protein-2 via a mechanism involving the Wnt/β-catenin pathway

S Rong, X Zhao, X Jin, Z Zhang, L Chen… - Cellular Physiology and …, 2014 - karger.com
Background: Vascular calcification (VC), in which vascular smooth muscle cells (VSMCs)
undergo a phenotypic transformation into osteoblast-like cells, is one of the emergent risk …

DNMT1 and HDAC2 cooperate to facilitate aberrant promoter methylation in inorganic phosphate-induced endothelial-mesenchymal transition

X Tan, X Xu, M Zeisberg, EM Zeisberg - PLoS One, 2016 - journals.plos.org
While phosphorus in the form of inorganic or organic phosphate is critically involved in most
cellular functions, high plasma levels of inorganic phosphate levels have emerged as …