We report that a low-calorie diet can lessen the severity of neurochemical deficits and motor
dysfunction in a primate model of Parkinson's disease. Adult male rhesus monkeys were …

Glial cell line‐derived neurotrophic factor (GDNF) promotes survival of mesencephalic
dopaminergic neurons in vitro and when injected locally into the brains of lesioned adult …

Dietary restriction (DR; reduced calorie intake) increases the lifespan of rodents and
increases their resistance to cancer, diabetes and other age‐related diseases. DR also …

Despite numerous clinical studies supporting a link between type 2 diabetes (T2D) and
Parkinson's disease (PD), the clinical literature remains equivocal. We, therefore, sought to …

Although a good deal is known about the pathophysiology of Parkinson's disease and
information is emerging about its cause, there are no pharmacological treatments shown to …

Although the gene defect responsible for Huntington disease (HD) has recently been
identified, the pathogenesis of the disease remains obscure. One potential mechanism is …

The adult brain contains neural stem cells that are capable of proliferating, differentiating
into neurons or glia, and then either surviving or dying. This process of neural-cell …

Exercise is thought to improve motor function and emotional well-being in patients with
Parkinson's disease (PD). However, it is not clear if the improvements are due to …

There is clinical evidence that the symptoms of Parkinson's disease can be ameliorated by
physical exercise, and we have been using animal models to explore the hypothesis that …

Glial cell line‐derived neurotrophic factor (GDNF) promotes recovery of the injured
nigrostriatal dopamine system and improves motor functions in both rodent and nonhuman …