Genetics play a prominent role in both determination of thyroid hormone and thyrotropin
(TSH) concentrations, and susceptibility to autoimmune thyroid disease. Heritability studies …

Serum thyroid parameters show substantial inter-individual variability, in which genetic
variation is a major factor. Findings in patients with subclinical hyper-and hypothyroidism …

Recent studies have confirmed that polymorphisms in several genes confer susceptibility for
the development of autoimmune thyroid disease, and that of these HLA-DR alleles, and the …

Abstract Effects of thyroid hormones in individual tissues are determined by many factors
beyond their serum levels, including local deiodination and expression and activity of thyroid …

In many instances, the pathophysiology of thyroid dysgenesis (TD) remains as yet unclear
and until relatively recently the disorder was usually regarded as occurring in a sporadic …

Mutations arise as a change in the coding sequence of a gene. Point mutations occur when
another replaces one base. Insertions and deletions are the addition and removal of one or …

Thyroid dysgenesis (TD) is the most prevalent form of congenital hypothyroidism. Ttf-1, Ttf-2,
Pax8 and the Tshr are expressed at early stages of thyroid development and are implicated …

Abstract Development and differentiation of the thyroid gland is directed by expression of
specific transcription factors in the thyroid follicular cell which mediates hormone …

Normal thyroid function is essential for development, growth, and metabolic homeostasis.
The prerequisites for an euthyroid metabolic state include a normally developed thyroid …

Single nucleotide polymorphisms (SNPs) in genes involved in thyroid hormone metabolism
may affect thyroid hormone bioactivity. We investigated the occurrence and possible effects …