Abstract mRNA transport in neurons requires formation of transport granules containing
many protein components, and subsequent alterations in phosphorylation status can …

Trafficking of mRNA molecules from the nucleus to distal processes in neural cells is
mediated by heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 trans‐acting factors …

Liquid–liquid phase separation of proteins and nucleic acids into membraneless organelles
(MLOs) spatially organizes cellular components and reactions. The RNA-binding protein …

Myelin basic protein (MBP) is a major component of central nervous system (CNS) myelin.
The absence of MBP results in the loss of almost all compact myelin in the CNS. MBP mRNA …

The Nrf family of transcription factors plays a critical role in mediating adaptive responses to
cellular stress and defends against neurodegeneration, aging, and cancer. Here, we report …

Abstract hnRNPA2 is a major component of mRNA transport granules in oligodendrocytes
and neurons. However, the structural details of how hnRNPA2 binds the A2 recognition …

In the past year, several key molecular components of the RNA trafficking pathway in
myelinating cells have been identified: distinct cis-acting elements for RNA transport and …

Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive disorder of unknown
etiology characterized by the selective degeneration of motor neurons. Recent evidence …

Upon nuclear export, RNP particles are either localized to polysomes or further assembled
into larger RNA granules which are transported to the cellular periphery for localized …

Heterogeneous ribonucleoprotein (hnRNP) A2 is a trans-acting factor that mediates
intracellular trafficking of specific RNAs containing the A2 response element. HnRNP A2 is …