[HTML][HTML] Impact of CYP3A5 Polymorphisms on Pediatric Asthma Outcomes

FL Nkoy, BL Stone, CE Deering-Rice, A Zhu… - International Journal of …, 2024 - mdpi.com
Genetic variation among inhaled corticosteroid (ICS)-metabolizing enzymes may affect
asthma control, but evidence is limited. This study tested the hypothesis that single …

The Cytochrome P450 (CYP) 2C8* 3 Variant (rs11572080) is Associated with Improved Asthma Symptom Control in Children and Altered Lipid Mediator Production …

M Almestica-Roberts, ND Nguyen, L Sun… - Drug Metabolism and …, 2024 - ASPET
This study investigated an association between the cytochrome P450 (CYP) 2C8* 3
polymorphism with asthma symptom control in children and changes in lipid metabolism and …

Association of a CYP3A5 gene polymorphism with exacerbation in adult patients with asthma

S Uehara, K Hirai, T Shirai, K Itoh - The Journal of Allergy and Clinical …, 2024 - Elsevier
Association of a CYP3A5 gene polymorphism with exacerbation in adult patients with
asthma Page 1 Journal Pre-proof Association of a CYP3A5 gene polymorphism with …

Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids

HW Park, A Dahlin, S Tse, QL Duan… - Journal of Allergy and …, 2014 - Elsevier
Background To date, genome-wide association studies (GWASs) of inhaled corticosteroid
(ICS) response in asthmatic patients have focused primarily on lung function and …

Fluticasone propionate pharmacogenetics: CYP3A4* 22 polymorphism and pediatric asthma control

C Stockmann, B Fassl, R Gaedigk, F Nkoy… - The Journal of …, 2013 - Elsevier
OBJECTIVE: To determine the relationship between allelic variations in genes involved in
fluticasone propionate (FP) metabolism and asthma control among children with asthma …

Effect of CYP3A5* 3 on asthma control among children treated with inhaled beclomethasone

C Stockmann, CA Reilly, B Fassl, R Gaedigk… - Journal of Allergy and …, 2015 - jacionline.org
LETTERS TO THE EDITOR 505 the dose did not significantly alter the b coefficient in any of
the models tested (P>. 5) and was not retained in final analyses. A total of 64 …

CYP2C19 gene polymorphism may be a risk factor for bronchial asthma

H Yildirim Yaroğlu, M Çalıkoğlu… - Medical Principles and …, 2010 - karger.com
Objective: The aim of the present study was to investigate whether the genetic polymorphism
of CYP2C19 plays a role in susceptibility to bronchial asthma. Subjects and Methods: 104 …

Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use

N Hernandez-Pacheco, SJ Vijverberg… - European …, 2021 - Eur Respiratory Soc
Rationale Substantial variability in response to asthma treatment with inhaled corticosteroids
(ICS) has been described among individuals and populations, suggesting the contribution of …

Leveraging electronic health records to assess the role of ADRB2 single nucleotide polymorphisms in predicting exacerbation frequency in asthma patients

N Sood, JJ Connolly, FD Mentch… - Pharmacogenetics …, 2018 - journals.lww.com
Asthma is the leading chronic disease in children. Several studies have identified genetic
biomarkers associated with susceptibility and severity in both adult and pediatric cases. In …

Childhood asthma and spirometric indices are associated with polymorphic markers of two vitamin D 25‐hydroxylase genes

TF Leung, SS Wang, MF Tang, AP Kong… - Pediatric Allergy and …, 2015 - Wiley Online Library
Background Polymorphic markers of vitamin D pathway genes have been associated with
asthma traits in different White populations. This study investigated the relationship between …