Genome-wide association study identifies two susceptibility loci for osteosarcoma
Osteosarcoma is the most common primary bone malignancy of adolescents and young
adults. To better understand the genetic etiology of osteosarcoma, we performed a …
adults. To better understand the genetic etiology of osteosarcoma, we performed a …
Frequency of pathogenic germline variants in cancer-susceptibility genes in patients with osteosarcoma
Importance Osteosarcoma, the most common malignant bone tumor in children and
adolescents, occurs in a high number of cancer predisposition syndromes that are defined …
adolescents, occurs in a high number of cancer predisposition syndromes that are defined …
A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma
Background Osteosarcoma (OS) is a bone malignancy which occurs primarily in
adolescents. Since it occurs during a period of rapid growth, genes important in bone …
adolescents. Since it occurs during a period of rapid growth, genes important in bone …
Using epidemiology and genomics to understand osteosarcoma etiology
SA Savage, L Mirabello - Sarcoma, 2011 - Wiley Online Library
Osteosarcoma is a primary bone malignancy that typically occurs during adolescence but
also has a second incidence peak in the elderly. It occurs most commonly in the long bones …
also has a second incidence peak in the elderly. It occurs most commonly in the long bones …
Molecular genetics of osteosarcoma
K Rickel, F Fang, J Tao - Bone, 2017 - Elsevier
Osteosarcoma is the predominant form of bone cancer, affecting mostly adolescents. Recent
progress made in molecular genetic studies of osteosarcoma has changed our view on the …
progress made in molecular genetic studies of osteosarcoma has changed our view on the …
The genetics of osteosarcoma
JW Martin, JA Squire, M Zielenska - Sarcoma, 2012 - Wiley Online Library
Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in
children and adolescents relative to other age groups. The etiology of this often aggressive …
children and adolescents relative to other age groups. The etiology of this often aggressive …
Analysis of Genes Critical for Growth Regulation Identifies Insulin-like Growth Factor 2 Receptor Variations with Possible Functional Significance as Risk Factors for …
SA Savage, K Woodson, E Walk, W Modi, J Liao… - … Biomarkers & Prevention, 2007 - AACR
Background: Osteosarcoma, the most common malignant primary bone tumor, typically
occurs during the adolescent growth spurt. Germ-line genetic variation in genes critical in …
occurs during the adolescent growth spurt. Germ-line genetic variation in genes critical in …
A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis
Osteosarcomas are sarcomas of the bone, derived from osteoblasts or their precursors, with
a high propensity to metastasize. Osteosarcoma is associated with massive genomic …
a high propensity to metastasize. Osteosarcoma is associated with massive genomic …
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors
BS Melin, JS Barnholtz-Sloan, MR Wrensch… - Nature …, 2017 - nature.com
Genome-wide association studies (GWAS) have transformed our understanding of glioma
susceptibility, but individual studies have had limited power to identify risk loci. We …
susceptibility, but individual studies have had limited power to identify risk loci. We …
Germline and somatic genetics of osteosarcoma—connecting aetiology, biology and therapy
DM Gianferante, L Mirabello, SA Savage - Nature Reviews …, 2017 - nature.com
Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …
cancer of bone, have changed very little over the past 30 years. The peak incidence of …