Purpose. In this paper we seek to verify the differences in dissolution behavior between
class I and class II drugs and to evaluate the suitability of two new physiologically based …

Purpose. To assess the usefulness of biorelevant dissolution tests in predicting food and
formulation effects on the absorption of four poorly soluble, lipophilic drugs. Methods …

In vitro dissolution tests are performed for new formulations to evaluate in vivo performance,
which is affected by the change of gastrointestinal (GI) physiology, in the GI tract. Thus, those …

Purpose. The dissolution behavior of two commercially availableglibenclamide formulations
was tested in various media. The aim of thestudy was to investigate whether the use of …

The purpose of the study was to design dissolution tests that were able to distinguish
between the behaviour of danazol under fasted and fed conditions, by using biorelevant …

Although several routes of administration can be considered for new drug entities, the most
popular remains the oral route. To predict the in vivo performance of a drug after oral …

No Heading Purpose. The aim of this research was to develop a pH-dependent canine
absorption model for studying pH effect on both dissolution in vitro and pharmacokinetics in …

Dissolution testing with biorelevant media has become widespread in the pharmaceutical
industry as a means of better understanding how drugs and formulations behave in the …

Pharmaceutical solid oral dosage forms must undergo dissolution in the intestinal fluids of
the gastrointestinal tract before they can be absorbed and reach the systemic circulation …

Dissolution tests are used for many purposes in the pharmaceutical industry: in the
development of new products, for quality control and, to assist with the determination of …