Metastasis is a crucial hallmark of cancer progression, which involves numerous factors
including the degradation of the extracellular matrix (ECM), the epithelial-to-mesenchymal …

Cancer is a multifaceted disease comprising a combination of genetic, metabolic and
signalling aberrations, which severely disrupt the normal homeostasis of cell growth and …

Both apoptosis and autophagy are highly conserved processes that besides their role in the
maintenance of the organismal and cellular homeostasis serve as a main target of tumor …

While the mechanisms underlying apoptosis and autophagy have been well characterized
over recent decades, another regulated cell death event, necroptosis, remains poorly …

The mechanisms of two programmed cell death pathways, autophagy, and apoptosis, are
extensively focused areas of research in the context of cancer. Both the catabolic pathways …

Apoptosis has long been recognized as a critical mechanism of programmed cell death that
is preserved among all eukaryotes and is involved in a variety of disease processes …

Metabolic and therapeutic stresses activate several signal transduction pathways that
regulate cell death and cell survival in cancer cells. Although decades of research unraveled …

Autophagy and apoptosis are catabolic pathways essential for organismal homeostasis.
Autophagy is normally a cell‐survival pathway involving the degradation and recycling of …

Metastasis and relapse account for the great majority of cancer-related deaths. Most
metastatic lesions are micro metastases that have the capacity to remain in a non-dividing …

In cancer therapy, a principle goal is to kill cancer cells while minimizing death of normal
cells. Traditional cytotoxic therapies and the newer agents that target specific signaling …