Long-lasting memories require specific gene expression programmes that are, in part,
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …

Neuronal histone acetylation has been postulated to be a mnemonic substrate and a target
for memory enhancers and neuropsychiatric drugs. Here we critically evaluate this view and …

Learning and memory are cognitive processes that are tightly regulated. A proper genome-
environment interaction is a pre-requisite for cognitive function. Epigenetic processes are …

Long-term memory formation requires transcription and protein synthesis. Over the past few
decades, a great amount of knowledge has been gained regarding the molecular players …

Over the past 30 years, lysine acetylation of histone and nonhistone proteins has become
established as a key modulator of gene expression regulating numerous aspects of cell …

INTRODUCTION: Epigenetic modifications, such as histone acetylation and deacetylation,
are responsible for maintaining chromatin stability. As such, they have been implicated in a …

The orchestrated expression of genes is essential for the development and survival of every
organism. In addition to the role of transcription factors, the availability of genes for …

Histone acetylation is an epigenetic modification that plays a critical role in chromatin
remodelling and transcriptional regulation. There is increasing evidence that epigenetic …

Neurodegenerative diseases of the central nervous system are often associated with
impaired learning and memory, eventually leading to dementia. An important aspect in pre …

Advancing our understanding of neuroplasticity and the development of novel therapeutics
based upon this knowledge is critical in order to improve the treatment and prevention of a …