Oxidative stress after stroke is associated with the inflammatory system activation in the
brain. The complement cascade, especially the degradation products of complement …

Background Complement promotes neuroinflammation and injury in models of stroke.
However, complement is also being increasingly implicated in repair and regeneration after …

The complement cascade has been implicated in ischemia/reperfusion injury, and recent
studies have shown that complement inhibition is a promising treatment option for acute …

Abstract Complement component C3 (C3), a key factor in the complement system, is heavily
involved in various inflammation-associated diseases. However, it remains obscure for its …

The complement system is an essential part of innate immunity, typically conferring
protection via eliminating pathogens and accumulating debris. However, the defensive …

The authors investigated the effect of the C1 inhibitor (C1-INH), the only known inhibitor of
complement C1, in a murine model of transient focal ischemia. Ischemia was induced by …

Complement activation can cause tissue damage in cerebral stroke by the release of
biologically potent activation products and impaired function of regulatory proteins. We …

Activation of the complement system propagates neuroinflammation and brain damage early
and chronically after traumatic brain injury (TBI). The complement system is complex and …

Background The complement cascade plays a deleterious role in multiple models of
ischemia/reperfusion (I/R) injury, including stroke. Investigation of the complement cascade …

Proinflammatory cytokines and chemokines are quickly upregulated in response to
ischemia/reperfusion (I/R) injury; however, the relationship between I/R-induced oxidative …