The hindbrain transcription factors Phox2b and Egr2 (also known as Krox20) are linked to
the development of the autonomic nervous system and rhombomere-related regulation of …

We are investigating neuronal circuits resulting from conservative developmental
mechanisms orchestrating the segmentation of the vertebrates hindbrain into compartments …

We have shown previously that the inactivation of the zinc finger gene Krox-20 affects
hindbrain segmentation, resulting in the elimination of rhombomeres 3 and 5. We …

Breathing in mammals starts in the foetus and acquires a vital importance at birth. The ability
to produce rhythmic motor behaviours linked to respiratory function is a property of the …

The retrotrapezoid nucleus (RTN) is a group of neurons in the rostral medulla, defined here
as Phox2b-, Vglut2-, neurokinin1 receptor-, and Atoh1-expressing cells in the parafacial …

Neural networks in the hindbrain generate the pattern of motor activity that sustains
breathing in mammals. Over the last years, increasing knowledge of the development and …

To obtain insights into the emergence of rhythmogenic circuits supporting respiration, we
monitored spontaneous activities in isolated brainstem and medullary transverse slice …

Inhibitory neurons make up a substantial fraction of the neurons in the preBötzinger complex
(preBötC), a site that is critical for mammalian eupneic breathing. We investigated the role of …

The brainstem pre-Bötzinger complex (preBötC) generates inspiratory breathing rhythms,
but which neurons comprise its rhythmogenic core? Dbx1-derived neurons may play the …

In the last few years, elucidation of the architecture of breathing control centres has reached
the cellular level. This has been facilitated by increasing knowledge of the molecular …