[HTML][HTML] Imidazole-pyridine hybrids as potent anti-cancer agents
B Aruchamy, C Drago, V Russo, GM Pitari… - European Journal of …, 2023 - Elsevier
In the current investigation, fifteen novel imidazole-pyridine-based molecules were
synthesized and tested against cell lines of the lung (H1299) and colon (HCT116) …
synthesized and tested against cell lines of the lung (H1299) and colon (HCT116) …
Design, synthesis, antineoplastic activity of new pyrazolo [3, 4-d] pyrimidine derivatives as dual CDK2/GSK3β kinase inhibitors; molecular docking study, and ADME …
In the current study, novel pyrazolo [3, 4-d] pyrimidine derivatives 5a–h were designed and
synthesized as targeted anti-cancer agents through dual CDK2/GSK-3β inhibition. The …
synthesized as targeted anti-cancer agents through dual CDK2/GSK-3β inhibition. The …
[HTML][HTML] Design and synthesis of novel imidazole derivatives possessing triazole pharmacophore with potent anticancer activity, and in silico ADMET with GSK-3β …
F Al-Blewi, SA Shaikh, A Naqvi, F Aljohani… - International journal of …, 2021 - mdpi.com
A library of novel imidazole-1, 2, 3-triazole hybrids were designed and synthesized based
on the hybrid pharmacophore approach. Therefore, copper (I) catalyzed click reaction of …
on the hybrid pharmacophore approach. Therefore, copper (I) catalyzed click reaction of …
Design, synthesis and evaluation of some 1, 6-disubstituted-1H-benzo [d] imidazoles derivatives targeted PI3K as anticancer agents
HW Ding, L Yu, M Bai, XC Qin, M Song, QC Zhao - Bioorganic Chemistry, 2019 - Elsevier
Abstract Phosphatidylinositol 3-kinase (PI3K) pathway regulates various cellular processes,
such as proliferation, growth, autophagy and apoptosis. Class I PI3K is frequently mutated …
such as proliferation, growth, autophagy and apoptosis. Class I PI3K is frequently mutated …
Design, synthesis and biological evaluation of N-alkyl or aryl substituted isoindigo derivatives as potential dual cyclin-dependent kinase 2 (CDK2)/glycogen synthase …
P Zhao, Y Li, G Gao, S Wang, Y Yan, X Zhan… - European Journal of …, 2014 - Elsevier
A series of N-alkyl or aryl substituted isoindigo derivatives have been synthesized and their
anti-proliferative activity was evaluated by Sulforhodamine B (SRB) assay. Some of the …
anti-proliferative activity was evaluated by Sulforhodamine B (SRB) assay. Some of the …
Synthesis, docking studies into CDK-2 and anticancer activity of new derivatives based pyrimidine scaffold and their derived glycosides
AAH Rahman, IF Nassar, AKF Shaban… - Mini Reviews in …, 2019 - ingentaconnect.com
Background & Objective: New diaryl-substituted pyrimidinedione compounds, their thioxo
derivatives as well as their bicyclic thiazole compounds were synthesized and …
derivatives as well as their bicyclic thiazole compounds were synthesized and …
Discovery of 3, 6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico …
A Sabt, WM Eldehna, T Al-Warhi… - Journal of Enzyme …, 2020 - Taylor & Francis
Human health in the current medical era is facing numerous challenges, especially cancer.
So, the therapeutic arsenal for cancer should be unremittingly enriched with novel small …
So, the therapeutic arsenal for cancer should be unremittingly enriched with novel small …
[HTML][HTML] Novel 7-chloro-4-aminoquinoline-benzimidazole hybrids as inhibitors of cancer cells growth: synthesis, antiproliferative activity, in silico ADME predictions …
In this study, new 7-chloro-4-aminoquinoline-benzimidazole compounds were synthesized
and characterized by NMR, MS, and elemental analysis. These novel hybrids differ in the …
and characterized by NMR, MS, and elemental analysis. These novel hybrids differ in the …
[HTML][HTML] Isatin-hydrazones with multiple Receptor Tyrosine Kinases (RTKs) inhibitory activity and in-silico binding mechanism
Recently, we have reported a series of isatin hydrazone, two of them, namely, 3-((2, 6-
dichlorobenzylidene) hydrazono) indolin-2-one (1) and 3-((2-chloro-6-fluorobenzylidene) …
dichlorobenzylidene) hydrazono) indolin-2-one (1) and 3-((2-chloro-6-fluorobenzylidene) …
Design, synthesis and molecular docking of novel substituted azepines as inhibitors of PI3K/Akt/TSC2/mTOR signaling pathway in colorectal carcinoma
A series of novel substituted azepines (2–7) was synthesized using both traditional and
ultrasonic techniques. The efficiency of the reaction rate and yield was improved by …
ultrasonic techniques. The efficiency of the reaction rate and yield was improved by …