Topographical guidance and chemotaxis are crucial factors for peripheral nerve
regeneration. This study describes the preparation of highly aligned poly (ε …

Our long-term goal is to develop an artificial implant as a conduit for axonal regeneration
after peripheral nerve injury. In this study, biodegradable, aligned poly-ε-caprolactone (PCL) …

Introducing concentration gradients of nerve growth factor (NGF) into conduits for repairing
of peripheral nerve injury is crucial for nerve regeneration and guidance. Herein, combining …

Recent bioengineering strategies for peripheral nerve regeneration have been focusing on
the development of alternative treatments for nerve repair. In this study, we incorporated …

Peripheral nerve injury results in significant sensory and motor functional deficits. Although
direct neurorrhaphy in the early phase may reduce its devastating effects, direct end-to-end …

Fibre structures represent a potential class of materials for the formation of synthetic nerve
conduits due to their biomimicking architecture. Although the advantages of fibres in …

Many neurotrophic factors have been shown to promote neurite outgrowth by improving the
microenvironment that is required for nerve regeneration. However, the delivery of these …

Peripheral nerve injury is a serious medical problem with limited surgical and clinical
treatment options. It is of great significance to integrate multiple guidance cues in one …

Peripheral nerve regeneration can be enhanced by the stimulation of formation of bands of
Büngner prior to implantation. Aligned electrospun poly (ε-caprolactone)(PCL) fibers were …

Rationale: Peripheral nerve injury (PNI) is a great challenge for regenerative medicine.
Nerve autograft is the gold standard for clinical PNI repair. Due to its significant drawbacks …