Homocysteine modification in protein structure/function and human disease

H Jakubowski - Physiological reviews, 2019 - journals.physiology.org
Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …

Roles of homocysteine in cell metabolism: old and new functions

MÁ Medina, JL Urdiales… - European journal of …, 2001 - Wiley Online Library
Mild hyperhomocysteinemia has been suggested as a new, independent risk factor for
cardiovascular disease. This fact has produced a new, increased interest in the study of …

[HTML][HTML] The molecular and cellular effect of homocysteine metabolism imbalance on human health

H Škovierová, E Vidomanová, S Mahmood… - International journal of …, 2016 - mdpi.com
Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid derived in
methionine metabolism. The increased level of Hcy in plasma, hyperhomocysteinemia, is …

Homocysteine metabolism and its relation to health and disease

KT Williams, KL Schalinske - Biofactors, 2010 - Wiley Online Library
Homocysteine is a metabolic intermediate in methyl group metabolism that is dependent on
a number of nutritional B‐vitamin cofactors. An emerging aspect of homocysteine …

[HTML][HTML] Homocysteine: biochemistry, molecular biology and role in disease

A Hermann, G Sitdikova - Biomolecules, 2021 - mdpi.com
Homocysteine is a non-proteinogenic sulfhydryl-containing amino acid derived from
methionine and is a homologue of cysteine. The concentration of homocysteine is regulated …

Mechanisms of homocysteine toxicity in humans

J Perła-Kaján, T Twardowski, H Jakubowski - Amino acids, 2007 - Springer
Homocysteine, a non-protein amino acid, is an important risk factor for ischemic heart
disease and stroke in humans. This review provides an overview of homocysteine influence …

[图书][B] Homocysteine in health and disease

R Carmel, DW Jacobsen - 2001 - books.google.com
High levels of homocysteine, a sulfur-containing amino acid derived from methionine, have
recently been identified as a very important risk factor in cardiovascular disease …

Molecular targeting of proteins by L-homocysteine: mechanistic implications for vascular disease

AV Glushchenko, DW Jacobsen - Antioxidants & redox signaling, 2007 - liebertpub.com
Hyperhomocysteinemia is an independent risk factor for cardiovascular disease,
complications of pregnancy, cognitive impairment, and osteoporosis. That elevated …

Homocysteine and homocysteine-related compounds: an overview of the roles in the pathology of the cardiovascular and nervous systems

D Djuric, V Jakovljevic, V Zivkovic… - Canadian Journal of …, 2018 - cdnsciencepub.com
Homocysteine, an amino acid containing a sulfhydryl group, is an intermediate product
during metabolism of the amino acids methionine and cysteine. Hyperhomocysteinemia is …

Homocysteine and redox signaling

CG Zou, R Banerjee - Antioxidants & redox signaling, 2005 - liebertpub.com
Homocysteine is a thiol-containing amino acid that has gained notoriety because its
elevation in the plasma is correlated with complex and multifactorial diseases, including …