Molecular basis of congenital lp (a) deficiency: a frequent apo (a)'null'mutation in caucasians

M Ogorelkova, A Gruber… - Human molecular …, 1999 - academic.oup.com
High plasma concentrations of lipoprotein (a)[Lp (a)], a covalent low-density lipoprotein-
apolipoprotein (a)[apo (a)] complex, are associated with coronary heart disease and stroke …

A common nonsense mutation in the repetitive Kringle IV‐2 domain of human apolipoprotein (a) results in a truncated protein and low plasma Lp (a)

W Parson, HG Kraft, H Niederstätter… - Human …, 2004 - Wiley Online Library
LPA, the gene coding for apolipoprotein (a)[apo (a)], is the major determinant of lipoprotein
(a)[Lp (a)] plasma levels, which are associated with risk for coronary heart disease (CHD) …

Genetic basis and pathophysiological implications of high plasma Lp (a) levels

AM Scanu - Journal of internal medicine, 1992 - Wiley Online Library
Lipoprotein (a) or Lp (a) is a genetic variant of plasma low density lipoproteins (LDL)
containing apoB100 covalently linked to apolipoprotein (a) or apo (a), the specific marker of …

Single nucleotide polymorphisms in exons of the apo (a) kringles IV types 6 to 10 domain affect Lp (a) plasma concentrations and have different patterns in Africans …

M Ogorelkova, HG Kraft, C Ehnholm… - Human molecular …, 2001 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is a complex of apolipoprotein (a)[apo (a)] and low-density
lipoprotein which is associated with atherothrombotic disease. Lp (a) plasma levels are …

Sequence polymorphisms in the apo (a) gene associated with specific levels of Lp (a) in plasma

V Mooser, FP Mancini, S Bopp… - Human molecular …, 1995 - academic.oup.com
Most of the Interindividual variations in plasma levels of lipoprotein (a)[Lp (a)] can be
attributed to sequence differences linked to the apolipoprotein (a)[apo (a)] locus. Plasma …

Apolipoprotein (a) gene accounts for greater than 90% of the variation in plasma lipoprotein (a) concentrations.

E Boerwinkle, CC Leffert, J Lin… - The Journal of …, 1992 - Am Soc Clin Investig
Plasma lipoprotein (a)[Lp (a)], a low density lipoprotein particle with an attached
apolipoprotein (a)[apo (a)], varies widely in concentration between individuals. These …

The apolipoprotein (a) gene: a transcribed hypervariable locus controlling plasma lipoprotein (a) concentration

HG Kraft, S Köchl, HJ Menzel, C Sandholzer… - Human genetics, 1992 - Springer
Abstract Lipoprotein (a)[Lp (a)] is a quantitative trait in human plasma. Lp (a) consists of a
low-density lipoprotein and the plasminogen-related apolipoprotein (a)[apo (a)]. The apo (a) …

Lipoprotein (a) in homozygous familial hypercholesterolemia

HG Kraft, A Lingenhel, FJ Raal… - … , and vascular biology, 2000 - Am Heart Assoc
Lipoprotein (a)[Lp (a)] is a quantitative genetic trait that in the general population is largely
controlled by 1 major locus—the locus for the apolipoprotein (a)[apo (a)] gene. Sibpair …

Significant impact of the+ 93 C/T polymorphism in the apolipoprotein (a) gene on Lp (a) concentrations in Africans but not in Caucasians: confounding effect of linkage …

HG Kraft, M Windegger, HJ Menzel… - Human molecular …, 1998 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is a quantitative genetic trait in human plasma associated
with atherothrombotic disease. The major determinant of Lp (a) concentration is the …

Genetics and metabolism of lipoprotein (a) and their clinical implications (Part 1).

H Dieplinger, F Kronenberg - Wiener Klinische Wochenschrift, 1999 - europepmc.org
The human plasma lipoprotein Lp (a) has gained considerable clinical interest as a
genetically determined risk factor for atherosclerotic vascular diseases. Numerous (including …