Compelling evidence from earlier studies suggests that the pancreatic beta cell is inherently
weak in its antioxidant defense mechanisms to face the burden of protecting itself against …

Background: Oxidative stress is a hallmark of many diseases. A growing body of evidence
suggests that hyperglycemia-induced oxidative stress plays an important role in pancreatic β …

Nutrient sensing mechanisms of carbohydrates, amino acids and lipids operate distinct
pathways that are essential for the adaptation to varying metabolic conditions. The role of …

Antioxidative defence mechanisms of pancreatic β-cells are particularly weak and can be
overwhelmed by redox imbalance arising from overproduction of reactive oxygen and …

Elevated cellular reactive species, which can be produced by diabetic serum conditions
such as elevated inflammatory cytokines, lipotoxicity or glucotoxicity contribute to islet beta …

Phagocyte-like NADPH oxidase (Nox2) has been shown to play regulatory roles in the
metabolic dysfunction of the islet β-cell under the duress of glucolipotoxic conditions and …

Oxidative stress is implicated in the pathogenesis of pancreatic β‐cell dysfunction that
occurs in both type 1 and type 2 diabetes. Nuclear factor E2‐related factor 2 (NRF2) is a …

Significance: Cytokines released in and around pancreatic islets during islet inflammation
are believed to contribute to impaired β cell function and β cell death during the …

Reactive oxygen species (ROS) are important mediators of cellular signal transduction
cascades such as proliferation, migration, and apoptosis. Chronic exposure of isolated β …

Although nitric oxide (NO) and oxidative stress both contribute to proinflammatory cytokine
toxicity in pancreatic β-cells during type 1 diabetes mellitus (T1DM) development, the …