Background: The cytokine osteopontin (OPN) is a potential key player in the
immunopathogenesis of multiple sclerosis (MS) and a candidate biomarker for disease …

Background: Osteopontin (OPN) is a pleiotropic protein with important roles in inflammation
and immunity that has been suggested as a candidate biomarker for disease activity in …

Osteopontin (OPN) is a pleiotropic integrin binding protein with functions in cell-mediated
immunity, inflammation, tissue repair, and cell survival. Recent studies have shown that OPN …

Identifying a reliable biomarker may accelerate diagnosis of multiple sclerosis (MS) and lead
to early management of the disease. Accumulating evidence suggest that cerebrospinal fluid …

Osteopontin (OPN) has been identified as the most prominent cytokine-encoding gene
expressed within multiple sclerosis (MS) lesions. Recently, we demonstrated that OPN …

Osteopontin (OPN) is a proinflammatory marker produced by systemic immune and central
nervous system (CNS) resident cells. We examined, if the level of OPN in the cerebrospinal …

Background Despite recent advances in therapy that have improved the overall disease
course in multiple sclerosis (MS), the prognosis at the outset remains unpredictable …

Objective To determine cerebrospinal fluid levels of osteopontin (OPN), a proinflammatory
cytokine that was found to be overexpressed in multiple sclerosis lesions and increased in …

The pro-inflammatory cytokine osteopontin has been found to be highly expressed in
multiple sclerosis lesions and plasma levels are increased during relapses in relapse-onset …

Osteopontin (OPN) was suggested to have a role in the pathophysiology of MS and in bone
metabolism. However, we formerly reported increased presence of osteoporosis in MS …