Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic …

B Pitt, L Kober, P Ponikowski… - European heart …, 2013 - academic.oup.com
Abstract Aims Mineralocorticoid receptor antagonists (MRAs) improve outcomes in patients
with heart failure and reduced left ventricular ejection fraction (HFrEF), but their use is limited …

Rationale and design of ARTS: a randomized, double-blind study of BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease

B Pitt, G Filippatos, M Gheorghiade… - European journal of …, 2012 - Wiley Online Library
Aims BAY 94-8862 is a novel, non-steroidal, mineralocorticoid receptor antagonist with
greater selectivity than spironolactone and stronger mineralocorticoid receptor binding …

Safety of continuing mineralocorticoid receptor antagonist treatment in patients with heart failure with reduced ejection fraction and severe kidney disease: Data from …

F Guidetti, LH Lund, L Benson, C Hage… - European Journal of …, 2023 - Wiley Online Library
ABSTRACT Aims Mineralocorticoid receptor antagonists (MRAs) improve outcomes in heart
failure with reduced ejection fraction (HFrEF) but remain underused and are often …

Mineralocorticoid receptor antagonist pattern of use in heart failure with reduced ejection fraction: findings from BIOSTAT‐CHF

JP Ferreira, P Rossignol, JL Machu… - European journal of …, 2017 - Wiley Online Library
Abstract Aims Mineralocorticoid receptor antagonists (MRAs) are recommended (unless
contraindicated) to all patients with heart failure with reduced ejection fraction (HFrEF) …

Mineralocorticoid receptor antagonists in patients with heart failure: current experience and future perspectives

B Pitt, J Pedro Ferreira, F Zannad - European Heart Journal …, 2017 - academic.oup.com
The 2016 European Society of Cardiology Heart Failure society as well as the 2016
American Heart Association/American College of Cardiology/Heart Failure Society of …

Mineralocorticoid receptor antagonists for heart failure with reduced ejection fraction: integrating evidence into clinical practice

F Zannad, W Gattis Stough, P Rossignol… - European heart …, 2012 - academic.oup.com
Mineralocorticoid receptor antagonists (MRAs) improve survival and reduce morbidity in
patients with heart failure, reduced ejection fraction (HF–REF), and mild-to-severe …

New mineralocorticoid receptor antagonists: update on their use in chronic kidney disease and heart failure

I Capelli, L Gasperoni, M Ruggeri, G Donati… - Journal of …, 2020 - Springer
Aldosterone is a mineralocorticoid hormone with a well-known effect on the renal tubule
leading to water retention and potassium reabsorption. Other major effects of the hormone …

Factors associated with underuse of mineralocorticoid receptor antagonists in heart failure with reduced ejection fraction: an analysis of 11 215 patients from the …

G Savarese, JJ Carrero, B Pitt, SD Anker… - European journal of …, 2018 - Wiley Online Library
Aim Mineralocorticoid receptor antagonists (MRAs) improve outcomes in heart failure with
reduced ejection fraction (HFrEF), but are underutilized. Hyperkalaemia may be one reason …

Rationale and design of MinerAlocorticoid Receptor antagonist Tolerability Study‐Heart Failure (ARTS‐HF): a randomized study of finerenone vs. eplerenone in …

B Pitt, SD Anker, M Böhm… - European journal of …, 2015 - Wiley Online Library
Aims To investigate the safety and potential efficacy of the novel non‐steroidal
mineralocorticoid receptor antagonist finerenone in patients with worsening chronic heart …

Sex differences in mineralocorticoid receptor antagonist trials: a pooled analysis of three large clinical trials

X Rossello, JP Ferreira, SJ Pocock… - European journal of …, 2020 - Wiley Online Library
Aims Women with heart failure (HF) are under‐represented in individual randomized clinical
trials (RCTs). Little is known about sex‐specific treatment effects in HF medications. We …