Interleukin‐23: as a drug target for autoimmune inflammatory diseases
Summary Interleukin‐23 (IL‐23) is a member of the IL‐12 family of cytokines with pro‐
inflammatory properties. Its ability to potently enhance the expansion of T helper type 17 …
inflammatory properties. Its ability to potently enhance the expansion of T helper type 17 …
IL‐23: one cytokine in control of autoimmunity
During the past decade, it has been firmly established that IL‐23 is essential for disease
development in several models of autoimmune disease, including psoriatic skin …
development in several models of autoimmune disease, including psoriatic skin …
IL-12-and IL-23 in health and disease
AL Croxford, P Kulig, B Becher - Cytokine & growth factor reviews, 2014 - Elsevier
Abstract Interleukin (IL)-12 and IL-23 play important roles in the development of
experimental autoimmune disease models and numerous afflictions affecting humans …
experimental autoimmune disease models and numerous afflictions affecting humans …
Interleukin-22: a likely target for treatment of autoimmune diseases
X Yang, SG Zheng - Autoimmunity reviews, 2014 - Elsevier
Abstract Interleukin-22 (IL-22) is a member of IL-10 family cytokines that is produced by
many different types of lymphocytes including both those of the innate and adaptive immune …
many different types of lymphocytes including both those of the innate and adaptive immune …
Understanding the IL-23–IL-17 immune pathway
BS McKenzie, RA Kastelein, DJ Cua - Trends in immunology, 2006 - cell.com
Interleukin (IL)-23 is a heterodimeric cytokine closely related to IL-12. Yet, despite a strong
structural relationship that includes a shared p40 subunit, this does not translate into …
structural relationship that includes a shared p40 subunit, this does not translate into …
Emerging role of interleukin-22 in autoimmune diseases
HF Pan, XP Li, SG Zheng, DQ Ye - Cytokine & growth factor reviews, 2013 - Elsevier
Interleukin-22 (IL-22) is an IL-10 family cytokine member that was recently discovered to be
mainly produced by Th17 cells. Previous studies have indicated the importance of IL-22 in …
mainly produced by Th17 cells. Previous studies have indicated the importance of IL-22 in …
Role of the IL-23/IL-17 pathway in rheumatic diseases: an overview
C Schinocca, C Rizzo, S Fasano, G Grasso… - Frontiers in …, 2021 - frontiersin.org
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19)
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …
IL‐22 and inflammation: Leukin'through a glass onion
LA Zenewicz, RA Flavell - European journal of immunology, 2008 - Wiley Online Library
IL‐22 is a Th17 T‐cell‐associated cytokine that is highly expressed during chronic
inflammation. IL‐22 receptor expression is absent on immune cells, but is instead restricted …
inflammation. IL‐22 receptor expression is absent on immune cells, but is instead restricted …
Divergent effects of IL‐12 and IL‐23 on the production of IL‐17 by human T cells
MA Hoeve, NDL Savage, T de Boer… - European journal of …, 2006 - Wiley Online Library
IL‐23 is regarded as a major pro‐inflammatory mediator in autoimmune disease, a role
which until recently was ascribed to its related cytokine IL‐12. IL‐23, an IL‐12p40/p19 …
which until recently was ascribed to its related cytokine IL‐12. IL‐23, an IL‐12p40/p19 …
Decoding IL-23 signaling cascade for new therapeutic opportunities
G Pastor-Fernández, IR Mariblanca, MN Navarro - Cells, 2020 - mdpi.com
The interleukin 23 (IL-23) is a key pro-inflammatory cytokine in the development of chronic
inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis …
inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis …