Interleukin‐23: as a drug target for autoimmune inflammatory diseases

C Tang, S Chen, H Qian, W Huang - Immunology, 2012 - Wiley Online Library
Summary Interleukin‐23 (IL‐23) is a member of the IL‐12 family of cytokines with pro‐
inflammatory properties. Its ability to potently enhance the expansion of T helper type 17 …

IL‐23: one cytokine in control of autoimmunity

AL Croxford, F Mair, B Becher - European journal of …, 2012 - Wiley Online Library
During the past decade, it has been firmly established that IL‐23 is essential for disease
development in several models of autoimmune disease, including psoriatic skin …

IL-12-and IL-23 in health and disease

AL Croxford, P Kulig, B Becher - Cytokine & growth factor reviews, 2014 - Elsevier
Abstract Interleukin (IL)-12 and IL-23 play important roles in the development of
experimental autoimmune disease models and numerous afflictions affecting humans …

Interleukin-22: a likely target for treatment of autoimmune diseases

X Yang, SG Zheng - Autoimmunity reviews, 2014 - Elsevier
Abstract Interleukin-22 (IL-22) is a member of IL-10 family cytokines that is produced by
many different types of lymphocytes including both those of the innate and adaptive immune …

Understanding the IL-23–IL-17 immune pathway

BS McKenzie, RA Kastelein, DJ Cua - Trends in immunology, 2006 - cell.com
Interleukin (IL)-23 is a heterodimeric cytokine closely related to IL-12. Yet, despite a strong
structural relationship that includes a shared p40 subunit, this does not translate into …

Emerging role of interleukin-22 in autoimmune diseases

HF Pan, XP Li, SG Zheng, DQ Ye - Cytokine & growth factor reviews, 2013 - Elsevier
Interleukin-22 (IL-22) is an IL-10 family cytokine member that was recently discovered to be
mainly produced by Th17 cells. Previous studies have indicated the importance of IL-22 in …

Role of the IL-23/IL-17 pathway in rheumatic diseases: an overview

C Schinocca, C Rizzo, S Fasano, G Grasso… - Frontiers in …, 2021 - frontiersin.org
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19)
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …

IL‐22 and inflammation: Leukin'through a glass onion

LA Zenewicz, RA Flavell - European journal of immunology, 2008 - Wiley Online Library
IL‐22 is a Th17 T‐cell‐associated cytokine that is highly expressed during chronic
inflammation. IL‐22 receptor expression is absent on immune cells, but is instead restricted …

Divergent effects of IL‐12 and IL‐23 on the production of IL‐17 by human T cells

MA Hoeve, NDL Savage, T de Boer… - European journal of …, 2006 - Wiley Online Library
IL‐23 is regarded as a major pro‐inflammatory mediator in autoimmune disease, a role
which until recently was ascribed to its related cytokine IL‐12. IL‐23, an IL‐12p40/p19 …

Decoding IL-23 signaling cascade for new therapeutic opportunities

G Pastor-Fernández, IR Mariblanca, MN Navarro - Cells, 2020 - mdpi.com
The interleukin 23 (IL-23) is a key pro-inflammatory cytokine in the development of chronic
inflammatory diseases, such as psoriasis, inflammatory bowel diseases, multiple sclerosis …