The influence of genes in cancer development shows different intensities, and it is mediated
by diverse mechanisms. It is well known that some cancer types are more linked with the …

The immune system, a system with an undeniable but complex role in malignancies
significantly can influence the face of malignancy with respect to predisposition, nature …

The immune system keeps the host body safe and protected from diseases. Genetic
diseases can often manipulate the immune genes at genetic levels so that the proteins in …

Approximately 10% of cancers have a hereditary predisposition. However, no genetic
diagnosis is available in 60%-80% of familial cancers. In some of these families, immune …

Numerous concepts of cancer pathogenesis have been proposed to further a better
understanding of human cancer development. Although there is general agreement about …

For a long time, the lack of a human-centered translational approach to tumor immunology
has led to the accumulation of a multitude of disjointed clinical and basic researches …

The immune system has a critical tumor suppressor function via the detection and
elimination of the tumor cells. Tumor cells' immune escaping is commonly observed during …

Cancer is a group of more than 100 different diseases, which is defined as the uncontrolled
growth of abnormal cells that can penetrate and spread to other parts of the body. Human …

Genetic markers and polymorphisms play a pivotal role in determining an individual's
susceptibility to cancer and their prognosis. These variations can influence various aspects …

Abstract Potentially Malignant Disorders have increased risk of malignancy which is present
either at time of initial diagnosis or at a future date. Although etiological factors are many, but …