[HTML][HTML] Role of ROS/RNS in preeclampsia: are connexins the missing piece?

MF Rozas-Villanueva, P Casanello… - International Journal of …, 2020 - mdpi.com
Preeclampsia is a pregnancy complication that appears after 20 weeks of gestation and is
characterized by hypertension and proteinuria, affecting both mother and offspring. The …

[HTML][HTML] Nitric oxide and reactive oxygen species in the pathogenesis of preeclampsia

K Matsubara, T Higaki, Y Matsubara… - International journal of …, 2015 - mdpi.com
Preeclampsia (PE) is characterized by disturbed extravillous trophoblast migration toward
uterine spiral arteries leading to increased uteroplacental vascular resistance and by …

Preeclampsia: current understanding of the molecular basis of vascular dysfunction

S Sankaralingam, IA Arenas, MM Lalu… - Expert reviews in …, 2006 - cambridge.org
Preeclampsia is a pregnancy-specific disorder characterised by hypertension and
proteinuria occurring after the 20th week of gestation. Delivery of the placenta results in …

The role of oxidative stress, adhesion molecules and antioxidants in preeclampsia

K Haram, JH Mortensen, O Myking… - Current hypertension …, 2019 - ingentaconnect.com
Oxidative stress is a consequence of reduction in the antioxidant capacity and excessive
production of reactive oxygen and nitrogen species (ROS). Oxidative agents, which are …

New perspectives on preeclampsia

C Mehats, F Miralles, D Vaiman - Medecine Sciences: M/S, 2017 - europepmc.org
Preeclampsia is a major, frequent and potentially severe condition of pregnancy,
characterized by severe hypertension and proteinuria. In this review, we describe recent …

Oxidative stress in pregnancy complicated by preeclampsia

S San Juan-Reyes, LM Gómez-Oliván… - Archives of biochemistry …, 2020 - Elsevier
Preeclampsia is a multisystemic disorder of pregnancy that causes perinatal morbidity and
mortality. Studies published in the last decade have contributed to a better understanding of …

Oxidative stress as a key signaling pathway in placental angiogenesis changes in preeclampsia: updates in pathogenesis, novel biomarkers and therapeutics

EO Anto, P Roberts, CA Turpin… - Current …, 2018 - ingentaconnect.com
Background: Preeclampsia (PE) is a disorder of pregnancy characterised by persistent high
blood pressure and proteinuria, which is usually detected after 20 weeks gestation. The …

[HTML][HTML] Preeclampsia: novel mechanisms and potential therapeutic approaches

Z Armaly, JE Jadaon, A Jabbour, ZA Abassi - Frontiers in physiology, 2018 - frontiersin.org
Preeclampsia is a serious complication of pregnancy where it affects 5–8% of all
pregnancies. It increases the morbidity and mortality of both the fetus and pregnant woman …

[HTML][HTML] Vascular dysfunction in preeclampsia

MA Opichka, MW Rappelt, DD Gutterman, JL Grobe… - Cells, 2021 - mdpi.com
Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …

Oxygen sensitivity of placental trophoblast connexins 43 and 46: a role in preeclampsia?

T Otto, A Gellhaus, N Lüschen… - Journal of Cellular …, 2015 - Wiley Online Library
Several gap junction connexins have been shown to be essential for appropriate placental
development and function. It is known that the expression and distribution of connexins …