Immunoglobulin G4-related sialadenitis (IgG4-RS) is an immune-mediated fibro-
inflammatory disease and the pathogenesis is still not fully understood. The aim of this study …

CD4+ Foxp3+ Tregs maintain immune homeostasis, but distinct mechanisms underlying
their functional heterogeneity during infections are driven by specific cytokine milieu. Here …

Abstract Objectives/Hypothesis: Immunoglobulin G4 (IgG4)‐related sclerosing sialadenitis is
a recently recognized disease entity characterized by high serum IgG4 concentration and …

Objectives Interleukin (IL)-21 is mainly produced by CD4 T helper (Th) cells including Th2,
Th17 and follicular helper T (Tfh) cells. Recent studies have reported that IL-21 is involved in …

Specific cytokines and the costimulatory protein CD40 play role in inducing immunoglobulin
(Ig) A production by B cells in the humoral immune response. However, to date, the role of …

Background The human salivary gland (HSG) cell line has so far been used as in vitro
models for study of the influence of cytokines and pharmacologic agents on salivary glands …

Previous studies have evaluated the roles of T and B cells in the pathogenesis of Sjögren's
syndrome (SS); however, their relationships with age-dependent and metabolic …

Increased interleukin (IL)-17 and IL-23 levels exist in the gingival tissue of periodontitis
patients, but the precise molecular mechanisms that regulate IL-17 and IL-23 production …

Macrophage pyroptosis drives the secretion of IL-1β, which has been recently reported to be
a featured salivary biomarker for discriminating periodontitis in the presence of diabetes …

Objectives This study aims to determine a role of interleukin‐17A (IL‐17) in salivary gland
(SG) dysfunction and therapeutic effects of targeting IL‐17 in SG for treating autoimmune …