Autoimmune mediated inflammation and renal damage in lupus nephritis (LN) depends
partly on the infiltration of lymphocytes in glomeruli and renal interstitium. Here we identified …

In systemic lupus erythematosus, CD4+ T cells play key roles in the initiation and promotion
of autoantigen-specific humoral immunity, and indirect evidence suggests that T cells are …

Autoreactive T cells are critical in the initiation and maintenance of autoantibody responses
that are a hallmark of systemic lupus erythematosus. However, the direct contribution of T …

Autoreactive kidney-infiltrating T-cell clones in murine lupus nephritis. T-cells have been
implicated in autoimmune renal injury. To examine the role of T-cells in lupus nephritis we …

While T cells are important for the pathogenesis of systemic lupus erythematosus (SLE) and
lupus nephritis, little is known about how T cells function after infiltrating the kidney. The …

Lupus nephritis (LN) is a major manifestation of systemic lupus erythematosus (SLE),
causing morbidity and mortality in 40–60% of SLE patients. The pathogenic mechanisms of …

An acquired deficiency of interleukin-2 (IL-2) and related disturbances in regulatory T cell
(Treg) homeostasis play an important role in the pathogenesis of systemic lupus …

Systemic lupus erythematosus is a systemic and chronic autoimmune disease characterized
by loss of tolerance towards nuclear antigens with autoreactive CD4+ T cells implicated in …

Although tissue-resident-memory T (T RM) cells, a recently identified non-circulating
memory T cell population, play a crucial role in mediating local immune responses and …

Objectives In patients with systemic lupus erythematosus (SLE), immune tolerance
breakdown leads to autoantibody production and immune-complex glomerulonephritis. This …