Cleavage of huntingtin (htt) has been characterized in vitro, and accumulation of caspase
cleavage fragments represents an early pathological change in brains of Huntington's …

Caspase cleavage of huntingtin (htt) and nuclear htt accumulation represent early
neuropathological changes in brains of patients with Huntington's disease (HD). However …

Proteolysis of mutant huntingtin is crucial to the development of Huntington disease (HD).
Specifically preventing proteolysis at the capase-6 (C6) consensus sequence at amino acid …

Huntington's disease (HD) results from polyglutamine expansion in huntingtin (htt), a protein
with several consensus caspase cleavage sites. Despite the identification of htt fragments in …

Huntington Disease (HD) results from polyglutamine expansion within the N-terminus of
huntingtin. We have produced yeast artificial chromosome (YAC) transgenic mice …

The Huntington's disease (HD) mutation is a polyglutamine expansion in the N-terminal
region of huntingtin (N-htt). How neurons die in HD is unclear. Mutant N-htt aggregates in …

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative
disorder resulting in selective neuronal loss and dysfunction in the striatum and cortex. The …

Huntingtin is a caspase substrate, and loss of normal huntingtin function resulting from
caspase‐mediated proteolysis may play a role in the pathogenesis of Huntington disease …

Huntington's disease is a neurodegenerative disorder caused by CAG expansion that
results in expansion of a polyglutamine tract at the extreme N terminus of huntingtin (htt). htt …

Huntington's Disease is an inherited neurodegenerative disease that affects the medium
spiny neurons in the striatum. The disease is caused by the expansion of a polyglutamine …