FTO in cancer: functions, molecular mechanisms, and therapeutic implications
N 6-methyladenosine (m 6 A) is the most abundant internal modification in mRNA that
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …
[HTML][HTML] Targeting FTO suppresses cancer stem cell maintenance and immune evasion
Fat mass and obesity-associated protein (FTO), an RNA N 6-methyladenosine (m 6 A)
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
demethylase, plays oncogenic roles in various cancers, presenting an opportunity for the …
[HTML][HTML] Critical enzymatic functions of FTO in obesity and cancer
Fat mass and obesity-associated protein (FTO) single-nucleotide polymorphisms (SNPs)
have been linked to increased body mass and obesity in humans by genome-wide …
have been linked to increased body mass and obesity in humans by genome-wide …
Downregulation of the FTO m6A RNA demethylase promotes EMT-mediated progression of epithelial tumors and sensitivity to Wnt inhibitors
Post-transcriptional modifications of RNA constitute an emerging regulatory layer of gene
expression. The demethylase fat mass-and obesity-associated protein (FTO), an eraser of N …
expression. The demethylase fat mass-and obesity-associated protein (FTO), an eraser of N …
FTO-Dependent N6-Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling
Abstract N 6-Methyladenosine (m6A) is the most abundant modification of mammalian
mRNAs. RNA methylation fine tunes RNA stability and translation, altering cell fate. The fat …
mRNAs. RNA methylation fine tunes RNA stability and translation, altering cell fate. The fat …
[HTML][HTML] Targeting the RNA demethylase FTO for cancer therapy
LL Zhou, H Xu, Y Huang, CG Yang - RSC chemical biology, 2021 - pubs.rsc.org
N 6-Methyladenosine (m6A) is the most prevalent internal modification on mRNA and
represents a new layer of gene expression in eukaryotes. The field of m6A-encoded …
represents a new layer of gene expression in eukaryotes. The field of m6A-encoded …
Novel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression
JL Chen, B Du - Journal of cancer research and clinical oncology, 2019 - Springer
Purpose The fat mass-and obesity-associated (FTO) gene on chromosome 16q12. 2 shows
an intimate association with obesity and body mass index. Recently, research into the FTO …
an intimate association with obesity and body mass index. Recently, research into the FTO …
[HTML][HTML] FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
[HTML][HTML] FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis
DY Ruan, T Li, YN Wang, Q Meng, Y Li, K Yu, M Wang… - Oncogene, 2021 - nature.com
Fat mass and obesity-associated protein (FTO), an N6-methyladenosine (m6A)
demethylase, participates in tumor progression and metastasis in many malignancies, but its …
demethylase, participates in tumor progression and metastasis in many malignancies, but its …
FTO facilitates lung adenocarcinoma cell progression by activating cell migration through mRNA demethylation
Y Ding, N Qi, K Wang, Y Huang, J Liao… - OncoTargets and …, 2020 - Taylor & Francis
Background The fat mass and obesity-associated protein (FTO) was identified as a critical
demethylase involved in regulating cellular mRNA stability by removing N6 …
demethylase involved in regulating cellular mRNA stability by removing N6 …