Background—It has been shown that the activation of estrogen receptor-β (ER-β) plays an
important cardioprotective role against ischemia/reperfusion injury. However, the …

This study was designed to investigate whether treatment with an estrogen receptor-beta
(ER-β)-selective agonist (2, 3-bis (4-hydroxyphenyl)-propionitrile, DPN) can provide …

Steroid hormone receptors including estrogen receptors (ER) classically function as ligand-
regulated transcription factors. However, estrogens also elicit cellular effects through binding …

Premenopausal women exhibit endogenous cardioprotective signaling mechanisms that are
thought to result from the beneficial effects of estrogen, which we have shown to increase …

BACKGROUND: After ischemia/reperfusion (I/R) injury, female hearts demonstrate improved
functional recovery compared with male, which suggests a protective role for estrogen …

Rationale: Protein S-nitros (yl) ation (SNO) has been implicated as an essential mediator of
nitric oxide-dependent cardioprotection. Compared with males, female hearts exhibit higher …

We investigated the function of estrogen receptor-α in global myocardial ischemia and
reperfusion injury in male estrogen receptor-α knockout (ERKO) and wild-type mice. Mouse …

Aims Estrogen induces nitric oxide (NO) in the endothelium and appears to protect against
inflammation and atherosclerosis. NO can induce post-translational protein modifications …

Background: Estrogen has cardioprotective effects on ischemia/reperfusion (I/R). Tumor
necrosis factor alpha (TNFα) is an inflammatory cytokine with depressor effects on …

Background: Nitric oxide (NO) donors or facilitation of endogenous NO production is
cardioprotective. This study sought to determine whether enhanced myocardial NO …