Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome x-like alterations in adulthood of neonatally …

A Plagemann, T Harder, A Rake, M Voits, H Fink… - Brain research, 1999 - Elsevier
Overnutrition during critical developmental periods is suggested to be a risk factor for obesity
and associated metabolic disorders in later life. Underlying mechanisms are unknown …

Increased number of galanin-neurons in the paraventricular hypothalamic nucleus of neonatally overfed weanling rats

A Plagemann, T Harder, A Rake, K Melchior, W Rohde… - Brain research, 1999 - Elsevier
Perinatal overfeeding is a risk factor for overweight and diabetes during life. Underlying
pathophysiological mechanisms are unclear. The peptide galanin is suggested to stimulate …

Elevation of hypothalamic neuropeptide Y-neurons in adult offspring of diabetic mother rats

A Plagemann, T Harder, K Melchior, A Rake… - …, 1999 - journals.lww.com
WE recently reported on an elevation of neurons expressing the main orexigenic peptide
neuropeptide Y (NPY) in the arcuate hypothalamic nucleus (ARC) of neonatally …

Observations on the orexigenic hypothalamic neuropeptide Y‐system in neonatally overfed weanling rats

Plagemann, Harder, Rake, Waas… - Journal of …, 1999 - Wiley Online Library
Early postnatal overnutrition is a risk factor for obesity in juvenile and adult life. Underlying
pathophysiological mechanisms are still unclear. Hypothalamic neuropeptides are …

Malformations of hypothalamic nuclei in hyperinsulinemic offspring of rats with gestational diabetes

A Plagemann, T Harder, U Janert, A Rake… - Developmental …, 1999 - karger.com
Insulin is a potent modulator of central nervous development and is suggested to influence
the differentiation and maturation of hypothalamic structures involved in the regulation of …

Maternal high-fat diet and fetal programming: increased proliferation of hypothalamic peptide-producing neurons that increase risk for overeating and obesity

GQ Chang, V Gaysinskaya, O Karatayev… - Journal of …, 2008 - Soc Neuroscience
Recent studies in adult and weanling rats show that dietary fat, in close association with
circulating lipids, can stimulate expression of hypothalamic peptides involved in controlling …

Insulin resistance of hypothalamic arcuate neurons in neonatally overfed rats

H Davidowa, A Plagemann - Neuroreport, 2007 - journals.lww.com
Rats exposed to early postnatal overfeeding by rearing in small litters become hyperphagic,
hyperleptinemic, and hyperinsulinemic throughout later life. Medial arcuate neurons are …

Perinatal undernutrition-induced obesity is independent of the developmental programming of feeding

R Orozco-Sólis, SL de Souza, RJB Matos, I Grit… - Physiology & …, 2009 - Elsevier
Protein or calorie restriction during gestation and/or suckling induces hyperphagia and
increases the susceptibility to develop obesity, glucose intolerance and hypertension in …

[HTML][HTML] Hypothalamic nuclei are malformed in weanling offspring of low protein malnourished rat dams

A Plagemann, T Harder, A Rake, K Melchior… - The Journal of …, 2000 - Elsevier
Maternal low protein malnutrition during gestation and lactation (LP) is an animal model
frequently used for the investigation of long-term deleterious consequences of perinatal …

'Programming'of orexigenic and anorexigenic hypothalamic neurons in offspring of treated and untreated diabetic mother rats

K Franke, T Harder, L Aerts, K Melchior, S Fahrenkrog… - Brain research, 2005 - Elsevier
Exposure to maternal diabetes in utero (GD) may 'program'for obesity. Orexigenic
neuropeptides, like neuropeptide Y (NPY) and agouti-related peptide (AGRP), and …