Ferroptosis featured by iron‐dependent lipid peroxidation plays a critical role in tumor
regression, offering an alternative therapeutic target for the treatment of aggressive triple …

Triple negative breast cancer (TNBC), as the most aggressive BC, accounts for the leading
cause of worldwide women death. Owing to the deficiency of related hormone receptors, the …

The upregulation of dihydroorotate dehydrogenase (DHODH) redox systems inside tumor
cells provides a powerful shelter against lipid peroxidation (LPO), impeding ferroptosis …

Despite the therapeutic response of ferroptosis in various tumors, ferroptosis resistance has
been found in numerous studies, significantly hindering the progress of ferroptosis anti …

Radiotherapy (RT) is one of the important clinical treatments for local control of triple-
negative breast cancer (TNBC), but radioresistance still exists. Ferroptosis has been …

Restricted by the complex intracellular ferroptosis regulatory networks, single ferroptotic
therapy against breast cancer (BC) yields limited therapeutic outcomes. Therefore, novel …

Triple-negative breast cancer (TNBC), a management of aggressive breast cancer, remains
an unmet medical challenge. Although a wave of efforts had spurred to design novel …

Ferroptosis is a recently discovered route of regulated cell death that offers the opportunities
for the treatment of chemotherapy-resistant tumor indications, but its efficacy can be affected …

Despite its effectiveness in exterminating tumor cells, ferroptosis is seriously hampered by
the high expression of antioxidant glutathione (GSH) and the inadequacy of endogenous …

Apoptosis-based treatment plays an important role in regulating the death of tumor cells (eg,
chemotherapy, radiotherapy, and immunotherapy). Nevertheless, cancer cells can escape …