A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection

P Wang, R Luo, M Zhang, Y Wang, T Song, T Tao… - Cell death & …, 2020 - nature.com
Abstract COVID-19, caused by SARS-CoV-2, is an acute and rapidly developing pandemic,
which leads to a global health crisis. SARS-CoV-2 primarily attacks human alveoli and …

Biomimetic human disease model of SARS‐CoV‐2‐induced lung injury and immune responses on organ chip system

M Zhang, P Wang, R Luo, Y Wang, Z Li… - Advanced …, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is a global pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The models that can accurately …

Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

F D'Agnillo, KA Walters, Y Xiao, ZM Sheng… - Science translational …, 2021 - science.org
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is characterized by respiratory distress, multiorgan …

SARS-CoV-2 causes severe epithelial inflammation and barrier dysfunction

S Deinhardt-Emmer, S Böttcher, C Häring… - Journal of …, 2021 - Am Soc Microbiol
Infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can be
asymptomatic, but they can also be accompanied by a variety of symptoms that result in mild …

SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro

F Liu, K Han, R Blair, K Kenst, Z Qin, B Upcin… - Frontiers in cellular …, 2021 - frontiersin.org
SARS-CoV-2 infection can cause fatal inflammatory lung pathology, including thrombosis
and increased pulmonary vascular permeability leading to edema and hemorrhage. In …

Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients

J He, S Cai, H Feng, B Cai, L Lin, Y Mai, Y Fan… - Protein & …, 2020 - academic.oup.com
In 2019, a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) was identified as the causative agent of Coronavirus Disease 2019 (COVID …

[HTML][HTML] Endothelial cell infection and dysfunction, immune activation in severe COVID-19

Z Qin, F Liu, R Blair, C Wang, H Yang, J Mudd… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Pulmonary vascular endotheliitis, perivascular inflammation, and immune
activation are observed in COVID-19 patients. While the initial SARS-CoV-2 infection mainly …

The enigma of endothelium in COVID-19

S Kaur, DM Tripathi, A Yadav - Frontiers in Physiology, 2020 - frontiersin.org
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome–
related coronavirus-2 (SARS-CoV-2) has affected millions of people globally. Clinically, it …

Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes

NG Ravindra, MM Alfajaro, V Gasque, NC Huston… - PLoS …, 2021 - journals.plos.org
There are currently limited Food and Drug Administration (FDA)-approved drugs and
vaccines for the treatment or prevention of Coronavirus Disease 2019 (COVID-19) …

SARS-CoV-2 activates lung epithelial cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients

H Chen, W Liu, Y Wang, D Liu, L Zhao, J Yu - EBioMedicine, 2021 - thelancet.com
Abstract Background The outbreak of Coronavirus disease 2019 (COVID-19) caused by
SARS-CoV-2 infection has become a global health emergency. We aim to decipher SARS …