Mitochondrial complex II: at the crossroads
Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central
purveyor of the reprogramming of metabolic and respiratory adaptation in response to …
purveyor of the reprogramming of metabolic and respiratory adaptation in response to …
Assembly of mitochondrial succinate dehydrogenase in human health and disease
K Cao, J Xu, W Cao, X Wang, W Lv, M Zeng… - Free Radical Biology …, 2023 - Elsevier
Mitochondrial succinate dehydrogenase (SDH), also known as electron transport chain
(ETC) Complex II, is the only enzyme complex engaged in both oxidative phosphorylation …
(ETC) Complex II, is the only enzyme complex engaged in both oxidative phosphorylation …
Succinate dehydrogenase–assembly, regulation and role in human disease
Succinate dehydrogenase (or Electron Transport Chain Complex II) has been the subject of
a focused but significant renaissance. This complex, which has been the least studied of the …
a focused but significant renaissance. This complex, which has been the least studied of the …
Protein-mediated assembly of succinate dehydrogenase and its cofactors
Succinate dehydrogenase (or complex II; SDH) is a heterotetrameric protein complex that
links the tribarboxylic acid cycle with the electron transport chain. SDH is composed of four …
links the tribarboxylic acid cycle with the electron transport chain. SDH is composed of four …
Structure of the human respiratory complex II
Z Du, X Zhou, Y Lai, J Xu, Y Zhang… - Proceedings of the …, 2023 - National Acad Sciences
Human complex II is a key protein complex that links two essential energy-producing
processes: the tricarboxylic acid cycle and oxidative phosphorylation. Deficiencies due to …
processes: the tricarboxylic acid cycle and oxidative phosphorylation. Deficiencies due to …
Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but …
SJ Ralph, R Moreno-Sánchez, J Neuzil… - Pharmaceutical …, 2011 - Springer
Succinate: quinone reductase (SQR) of Complex II, occupying a unique central point in the
mitochondrial respiratory system as a major source of electrons driving reactive oxygen …
mitochondrial respiratory system as a major source of electrons driving reactive oxygen …
Genetic, epigenetic and biochemical regulation of succinate dehydrogenase function
B Moosavi, X Zhu, WC Yang, GF Yang - Biological Chemistry, 2020 - degruyter.com
Succinate dehydrogenase (SDH), complex II or succinate: quinone oxidoreductase (SQR) is
a crucial enzyme involved in both the tricarboxylic acid (TCA) cycle and oxidative …
a crucial enzyme involved in both the tricarboxylic acid (TCA) cycle and oxidative …
Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy
X Wang, X Zhang, K Cao, M Zeng, X Fu… - Nature …, 2022 - nature.com
Succinate dehydrogenase, which is known as mitochondrial complex II, has proven to be a
fascinating machinery, attracting renewed and increased interest in its involvement in …
fascinating machinery, attracting renewed and increased interest in its involvement in …
Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis
RD Guzy, B Sharma, E Bell, NS Chandel… - … and cellular biology, 2008 - Am Soc Microbiol
Mitochondrial complex II is a tumor suppressor comprised of four subunits (SdhA, SdhB,
SdhC, and SdhD). Mutations in any of these should disrupt complex II enzymatic activity, yet …
SdhC, and SdhD). Mutations in any of these should disrupt complex II enzymatic activity, yet …
Revisiting the TCA cycle: signaling to tumor formation
A role for mitochondria in tumor formation is suggested by mutations in enzymes of the TCA
cycle: isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH) and fumarate …
cycle: isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH) and fumarate …