Small molecule inhibitors have proven extremely useful for investigating signal transduction
pathways and have the potential for development into therapeutics for inhibiting signal …

Clinically, there is a great need for small molecule inhibitors that could control pathogenic
effects of transforming growth factor (TGF-β) and/or modulate effects of TGF-β in normal …

Transforming growth factor (TGF)‐β signaling facilitates tumor growth and metastasis in
advanced cancer. Use of inhibitors of TGF‐β signaling may thus be a novel strategy for the …

Optimization of the screening hit 1 led to the identification of novel 1, 5-naphthyridine
aminothiazole and pyrazole derivatives, which are potent and selective inhibitors of the …

Screening of our internal compound collection for inhibitors of the transforming growth factor
β1 (TGF-β1) type I receptor (ALK5) identified several hits. Optimization of the …

Activin receptor-like kinase 1 (ALK1), an endothelial cell-specific type I receptor of the TGF-β
superfamily, is an important regulator of normal blood vessel development as well as …

The bone morphogenetic protein (BMP) signaling pathway has essential functions in
development, homeostasis, and the normal and pathophysiologic remodeling of tissues …

Abstract Activin receptor–like kinase-1 (ALK1) is a type I, endothelial cell–specific member of
the transforming growth factor-β superfamily of receptors known to play an essential role in …

Human cDNA clones encoding four novel putative transmembrane protein serine/threonine
kinases, denoted activin receptor-like kinase (ALK)-1,-2,-3 and-4, were obtained using a …

Genetic and molecular studies suggest that activin receptor-like kinase 1 (ALK1), a
transforming growth factor β (TGF-β) type I receptor, and endoglin, a TGF-β co-receptor, play …