Macroautophagy is an essential degradative pathway that can be induced to clear
aggregated proteins, such as those found in Parkinson's disease and dementia with Lewy …

Cytoplasmic α-synuclein (α-syn) aggregates, referred to as Lewy bodies, are pathological
hallmarks of a number of neurodegenerative diseases, most notably Parkinson disease …

Progressive accumulation of α-synuclein is key to the pathology of many neurodegenerative
diseases, including Parkinson disease and dementia with Lewy bodies. Increased …

Abstract α‐Synuclein (α‐syn)‐containing glial cytoplasmic inclusions originating in
oligodendrocytes are characteristically observed in multiple system atrophy. The …

In neurodegenerative diseases, it remains unclear why certain brain regions are selectively
vulnerable to protein aggregation. In transgenic mice expressing human A53T α-synuclein …

Alpha-synuclein positive-intracytoplasmic inclusions are the common denominators of the
synucleinopathies present as Lewy bodies in Parkinson's disease, dementia with Lewy …

Background Lewy body disease is a heterogeneous group of neurodegenerative disorders
characterized by α-synuclein accumulation that includes dementia with Lewy bodies (DLB) …

The neuronal protein alpha-synuclein is thought to be central in the pathogenesis of
Parkinson's Disease (PD). Excessive wild type alpha-synuclein levels can lead to PD in …

Parkinson disease is characterized by the accumulation of aggregated α-synuclein as the
major component of the Lewy bodies. α-Synuclein accumulation in turn leads to …

Parkinson disease (PD) is the most common movement disorder affecting people. It is
characterized by the accumulation of the protein α-synuclein in Lewy body inclusions in …