Abstract Alpha-ketoglutarate (AKG), an endogenous intermediary metabolite in the Krebs
cycle, is a molecule involved in multiple metabolic and cellular pathways. It functions as an …

Alpha‐ketoglutarate (AKG) is a crucial intermediate of the Krebs cycle and plays a critical
role in multiple metabolic processes in animals and humans. Of note, AKG contributes to the …

The thriving field that constitutes cancer metabolism has unveiled some groundbreaking
facts over the past two decades, at the heart of which is the TCA cycle and its intermediates …

Alpha-Ketoglutarate (AKG) is a biological substance that plays important roles in cell
metabolism and physiology. AKG is synthesized from glucose or oxaloacetate plus pyruvate …

Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate
of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate …

In various organisms, an array of enzymes is involved in the synthesis and breakdown of
methylglyoxal. Through these enzymes, it is intimately linked to several other physiologically …

For many years, it has been clear that a Western diet rich in saturated fats and sugars
promotes an inflammatory environment predisposing a person to chronic cardiometabolic …

The fact that men and women are living longer than they have ever done before is
something in which we can all rejoice. However, the process of ageing is associated with …

Cancer cells enhance their glycolysis, producing lactate, even in the presence of oxygen.
Glycolysis is a series of ten metabolic reactions catalysed by enzymes whose expression is …

Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …