Osteogenesis imperfecta (OI), or brittle bone disease, is a heterogeneous disorder
characterised by bone fragility, multiple fractures, bone deformity, and short stature. OI is a …

The main clinical features of osteogenesis imperfecta (OI) are low bone mass and high bone
fragility. While the decrease in bone mass is generally regarded as an indicator of disease …

Osteogenesis imperfecta (OI) is characterized by severe bone deformities, growth
retardation and bones that break easily, often from little or no apparent cause. OI is a genetic …

Osteogenesis Imperfecta is the first translational reference professionals can turn to for a
source of comprehensive information on this disorder. Although several reviews of the field …

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Osteogenesis imperfecta is a skeletal dysplasia characterized by bone fragility and
extraskeletal manifestations. Better understanding of the mechanisms of osteogenesis …

Osteogenesis imperfecta (OI) can be a severe disorder that can be diagnosed before birth.
Transplantation of mesenchymal stem cells (MSC) has the potential to improve the bone …

Osteogenesis imperfecta (OI) is a monogenic bone fragility disorder that usually is caused
by mutations in one of the two genes coding for collagen type I alpha chains, COL1A1 or …

Osteogenesis imperfecta (OI) can be recognized prenatally with ultrasound. Transplantation
of mesenchymal stem cells (MSCs) has the potential to ameliorate skeletal damage. We …

Recently, the genetic heterogeneity in osteogenesis imperfecta (OI), proposed in 1979 by
Sillence et al., has been confirmed with molecular genetic studies. At present, 17 genetic …