Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice
K Krawczyk, S Xue, P Buchmann, G Charpin-El-Hamri… - Science, 2020 - science.org
Sophisticated devices for remote-controlled medical interventions require an electrogenetic
interface that uses digital electronic input to directly program cellular behavior. We present a …
interface that uses digital electronic input to directly program cellular behavior. We present a …
β-cell–mimetic designer cells provide closed-loop glycemic control
Chronically deregulated blood-glucose concentrations in diabetes mellitus result from a loss
of pancreatic insulin-producing β cells (type 1 diabetes, T1D) or from impaired insulin …
of pancreatic insulin-producing β cells (type 1 diabetes, T1D) or from impaired insulin …
An electrogenetic interface to program mammalian gene expression by direct current
J Huang, S Xue, P Buchmann, AP Teixeira… - Nature …, 2023 - nature.com
Wearable electronic devices are playing a rapidly expanding role in the acquisition of
individuals' health data for personalized medical interventions; however, wearables cannot …
individuals' health data for personalized medical interventions; however, wearables cannot …
A jump-start for electroceuticals
A jump-start for electroceuticals | Nature Skip to main content Thank you for visiting nature.com.
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You are using a browser version with limited support for CSS. To obtain the best experience …
Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles
Means for temporally regulating gene expression and cellular activity are invaluable for
elucidating underlying physiological processes and would have therapeutic implications …
elucidating underlying physiological processes and would have therapeutic implications …
Autonomous push button–controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant
H Zhao, S Xue, MD Hussherr, AP Teixeira… - Science …, 2022 - science.org
Traceless physical cues are desirable for remote control of the in situ production and real-
time dosing of biopharmaceuticals in cell-based therapies. However, current optogenetic …
time dosing of biopharmaceuticals in cell-based therapies. However, current optogenetic …
Surface-patterned electrode bioreactor for electrical stimulation
We present a microscale cell culture system with an interdigitated microarray of excimer-
laser-ablated indium tin oxide electrodes for electrical stimulation of cultured cells. The …
laser-ablated indium tin oxide electrodes for electrical stimulation of cultured cells. The …
Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics
Interfacing electronics with neural tissue is crucial for understanding complex biological
functions, but conventional bioelectronics consist of rigid electrodes fundamentally …
functions, but conventional bioelectronics consist of rigid electrodes fundamentally …
Endogenous bioelectrics in development, cancer, and regeneration: drugs and bioelectronic devices as electroceuticals for regenerative medicine
A major frontier in the post-genomic era is the investigation of the control of coordinated
growth and three-dimensional form. Dynamic remodeling of complex organs in regulative …
growth and three-dimensional form. Dynamic remodeling of complex organs in regulative …
Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice
J Shao, S Xue, G Yu, Y Yu, X Yang, Y Bai… - Science translational …, 2017 - science.org
With the increasingly dominant role of smartphones in our lives, mobile health care systems
integrating advanced point-of-care technologies to manage chronic diseases are gaining …
integrating advanced point-of-care technologies to manage chronic diseases are gaining …