Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice

K Krawczyk, S Xue, P Buchmann, G Charpin-El-Hamri… - Science, 2020 - science.org
Sophisticated devices for remote-controlled medical interventions require an electrogenetic
interface that uses digital electronic input to directly program cellular behavior. We present a …

β-cell–mimetic designer cells provide closed-loop glycemic control

M Xie, H Ye, H Wang, G Charpin-El Hamri, C Lormeau… - Science, 2016 - science.org
Chronically deregulated blood-glucose concentrations in diabetes mellitus result from a loss
of pancreatic insulin-producing β cells (type 1 diabetes, T1D) or from impaired insulin …

An electrogenetic interface to program mammalian gene expression by direct current

J Huang, S Xue, P Buchmann, AP Teixeira… - Nature …, 2023 - nature.com
Wearable electronic devices are playing a rapidly expanding role in the acquisition of
individuals' health data for personalized medical interventions; however, wearables cannot …

A jump-start for electroceuticals

K Famm, B Litt, KJ Tracey, ES Boyden, M Slaoui - Nature, 2013 - nature.com
A jump-start for electroceuticals | Nature Skip to main content Thank you for visiting nature.com.
You are using a browser version with limited support for CSS. To obtain the best experience …

Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles

SA Stanley, J Sauer, RS Kane, JS Dordick… - Nature medicine, 2015 - nature.com
Means for temporally regulating gene expression and cellular activity are invaluable for
elucidating underlying physiological processes and would have therapeutic implications …

Autonomous push button–controlled rapid insulin release from a piezoelectrically activated subcutaneous cell implant

H Zhao, S Xue, MD Hussherr, AP Teixeira… - Science …, 2022 - science.org
Traceless physical cues are desirable for remote control of the in situ production and real-
time dosing of biopharmaceuticals in cell-based therapies. However, current optogenetic …

Surface-patterned electrode bioreactor for electrical stimulation

N Tandon, A Marsano, R Maidhof, K Numata… - Lab on a Chip, 2010 - pubs.rsc.org
We present a microscale cell culture system with an interdigitated microarray of excimer-
laser-ablated indium tin oxide electrodes for electrical stimulation of cultured cells. The …

Metabolite-induced in vivo fabrication of substrate-free organic bioelectronics

X Strakosas, H Biesmans, T Abrahamsson, K Hellman… - Science, 2023 - science.org
Interfacing electronics with neural tissue is crucial for understanding complex biological
functions, but conventional bioelectronics consist of rigid electrodes fundamentally …

Endogenous bioelectrics in development, cancer, and regeneration: drugs and bioelectronic devices as electroceuticals for regenerative medicine

M Levin, J Selberg, M Rolandi - Iscience, 2019 - cell.com
A major frontier in the post-genomic era is the investigation of the control of coordinated
growth and three-dimensional form. Dynamic remodeling of complex organs in regulative …

Smartphone-controlled optogenetically engineered cells enable semiautomatic glucose homeostasis in diabetic mice

J Shao, S Xue, G Yu, Y Yu, X Yang, Y Bai… - Science translational …, 2017 - science.org
With the increasingly dominant role of smartphones in our lives, mobile health care systems
integrating advanced point-of-care technologies to manage chronic diseases are gaining …