Severe disease commonly manifests as a systemic inflammatory process. Inflammation is
associated withthe enhanced production of reactive oxygen and nitrogen species and with a …

Background Low levels of ascorbic acid (AA) have been detected in critically ill patients in
which AA supplementation leads to promising outcomes. However, the ability of AA to …

Ascorbic acid is a low molecular weight antioxidant well known as anti-scorbut acting
vitamin C in humans, primates and guinea pigs. This review summarizes basic data about …

Ascorbic acid (AA), also known as vitamin C, was initially identified as the factor preventing
the scurvy disease, and became very popular for its antioxidant properties. It is an important …

Ascorbic acid (AA), commonly known as vitamin C, plays an important role in the human
body, although its function at the cellular level is not yet clear. It is necessary for the synthe …

Oxidative stress is associated with reduced ascorbate levels. Ascorbate is particularly
effective in protecting the vascular endothelium, which is especially vulnerable to oxidative …

Oxidative stress has been proposed as a key contributor to lifestyle-and age-related
diseases. Because free radicals play an important role in various processes such as …

Ascorbic acid (vitamin C) elicits pleiotropic effects in the body. Among its functions, it serves
as a potent anti-oxidant, a co-factor in collagen and catecholamine synthesis, and a …

Background Parenterally administered ascorbic acid modulates sepsis-induced
inflammation and coagulation in experimental animal models. The objective of this …

Significance: Evidence is emerging that parenteral administration of high-dose vitamin C
may warrant development as an adjuvant therapy for patients with sepsis. Recent Advances …