[HTML][HTML] Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla
JL Bautista, NT Cramer, CN Miller, J Chavez… - Nature …, 2021 - nature.com
The thymus' key function in the immune system is to provide the necessary environment for
the development of diverse and self-tolerant T lymphocytes. While recent evidence suggests …
the development of diverse and self-tolerant T lymphocytes. While recent evidence suggests …
A 2020 view of thymus stromal cells in T cell development
J Han, JC Zúñiga-Pflücker - The Journal of Immunology, 2021 - journals.aai.org
The thymus is an intricate primary lymphoid organ, wherein bone marrow–derived lymphoid
progenitor cells are induced to develop into functionally competent T cells that express a …
progenitor cells are induced to develop into functionally competent T cells that express a …
Controlling the thymic microenvironment
DHD Gray, T Ueno, AP Chidgey, M Malin… - Current opinion in …, 2005 - Elsevier
T-cell development in the thymus is a stepwise process, mediated by a variety of stromal
cells in different regions of the organ. Although the cellular composition of the thymic …
cells in different regions of the organ. Although the cellular composition of the thymic …
[HTML][HTML] Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells
Invariant natural killer T (iNKT), mucosal-associated invariant T (MAIT), and γδ T cells are
innate T cells that acquire memory phenotype in the thymus and share similar biological …
innate T cells that acquire memory phenotype in the thymus and share similar biological …
Establishment and functioning of intrathymic microenvironments
The thymus supports the production of self‐tolerant T cells from immature precursors.
Studying the mechanisms regulating the establishment and maintenance of stromal …
Studying the mechanisms regulating the establishment and maintenance of stromal …
Thymic generation and regeneration
J Gill, M Malin, J Sutherland, D Gray… - Immunological …, 2003 - Wiley Online Library
The thymus is a complex epithelial organ in which thymocyte development is dependent
upon the sequential contribution of morphologically and phenotypically distinct stromal cell …
upon the sequential contribution of morphologically and phenotypically distinct stromal cell …
[HTML][HTML] Global transcriptional profiling reveals distinct functions of thymic stromal subsets and age-related changes during thymic involution
Age-associated thymic involution results in diminished T cell output and function in aged
individuals. However, molecular mediators contributing to the decline in thymic function …
individuals. However, molecular mediators contributing to the decline in thymic function …
[HTML][HTML] Key factors for thymic function and development
VP Shichkin, M Antica - Frontiers in Immunology, 2022 - frontiersin.org
The thymus is the organ responsible for T cell development and the formation of the
adaptive immunity function. Its multicellular environment consists mainly of the different …
adaptive immunity function. Its multicellular environment consists mainly of the different …
A cell atlas of human thymic development defines T cell repertoire formation
JE Park, RA Botting, C Domínguez Conde… - Science, 2020 - science.org
INTRODUCTION The thymus is the critical organ for T cell development and T cell receptor
(TCR) repertoire formation, which shapes the landscape of adaptive immunity. T cell …
(TCR) repertoire formation, which shapes the landscape of adaptive immunity. T cell …
Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells
T cell development and selection are coordinated in the thymus by a specialized niche of
diverse stromal populations,–. Although much progress has been made over the years in …
diverse stromal populations,–. Although much progress has been made over the years in …