How HIV Nef proteins hijack membrane traffic to promote infection
The accessory protein Nef of human immunodeficiency virus (HIV) is a primary determinant
of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of …
of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of …
HIV‐1 Nef: taking control of protein trafficking
EA Pereira, LLP daSilva - Traffic, 2016 - Wiley Online Library
The Nef protein of the human immunodeficiency virus is a crucial determinant of viral
pathogenesis and disease progression. Nef is abundantly expressed early in infection and …
pathogenesis and disease progression. Nef is abundantly expressed early in infection and …
Implications of Nef: host cell interactions in viral persistence and progression to AIDS
NJ Arhel, F Kirchhoff - HIV Interactions with Host Cell Proteins, 2009 - Springer
Abstract The HIV and SIV Nef accessory proteins are potent enhancers of viral persistence
and accelerate progression to AIDS in HIV-1-infected patients and non-human primate …
and accelerate progression to AIDS in HIV-1-infected patients and non-human primate …
[HTML][HTML] Structure–function relationships in HIV‐1 Nef
M Geyer, OT Fackler, BM Peterlin - EMBO reports, 2001 - embopress.org
The accessory Nef protein of HIV and SIV is essential for viral pathogenesis, yet it is
perplexing in its multitude of molecular functions. In this review we analyse the structure …
perplexing in its multitude of molecular functions. In this review we analyse the structure …
Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways
JF Roeth, KL Collins - Microbiology and molecular biology reviews, 2006 - Am Soc Microbiol
The Nef protein of primate lentiviruses is a unique protein that has evolved in several ways
to manipulate the biology of an infected cell to support viral replication, immune evasion …
to manipulate the biology of an infected cell to support viral replication, immune evasion …
Conformation of the Dileucine‐Based Sorting Motif in HIV‐1 Nef Revealed by Intermolecular Domain Assembly
FA Horenkamp, S Breuer, A Schulte, S Lülf, M Weyand… - Traffic, 2011 - Wiley Online Library
The human immunodeficiency virus 1 (HIV‐1) Nef protein is a pathogenicity factor required
for effective progression to AIDS, which modulates host cell signaling pathways and T‐cell …
for effective progression to AIDS, which modulates host cell signaling pathways and T‐cell …
HIV-1 Nef dimerization is required for Nef-mediated receptor downregulation and viral replication
JA Poe, TE Smithgall - Journal of molecular biology, 2009 - Elsevier
Nef, a human immunodeficiency virus type 1 (HIV-1) accessory factor capable of interaction
with a diverse array of host cell signaling molecules, is essential for high-titer HIV replication …
with a diverse array of host cell signaling molecules, is essential for high-titer HIV replication …
Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions
E Schaeffer, R Geleziunas, WC Greene - Journal of virology, 2001 - Am Soc Microbiol
The Nef protein of the type 1 human immunodeficiency virus (HIV-1) plays a key although
poorly understood role in accelerating the progression of clinical disease in vivo. Nef exerts …
poorly understood role in accelerating the progression of clinical disease in vivo. Nef exerts …
Structural basis of CD4 downregulation by HIV-1 Nef
Y Kwon, RM Kaake, I Echeverria, M Suarez… - Nature structural & …, 2020 - nature.com
The HIV-1 Nef protein suppresses multiple immune surveillance mechanisms to promote
viral pathogenesis and is an attractive target for the development of novel therapeutics. A …
viral pathogenesis and is an attractive target for the development of novel therapeutics. A …
HIV-1 Nef: a multifaceted modulator of T cell receptor signaling
L Abraham, OT Fackler - Cell communication and signaling, 2012 - Springer
Nef, an accessory protein of the Human Immunodeficiency Virus type 1 (HIV-1), is
dispensable for viral replication in cell culture, but promotes virus replication and …
dispensable for viral replication in cell culture, but promotes virus replication and …