Deleterious effect of gestagens from wastewater effluent on fish reproduction in aquatic environment: A review

JS Jenila, PK Issac, SS Lam, JC Oviya, S Jones… - Environmental …, 2023 - Elsevier
Gestagens are common pollutants accumulated in the aquatic ecosystem. Gestagens are
comprised of natural gestagens (ie progesterone) and synthetic gestagens (ie progestins) …

Progestins as endocrine disrupters in aquatic ecosystems: Concentrations, effects and risk assessment

K Fent - Environment international, 2015 - Elsevier
In aquatic ecosystems, progesterone (P4) and synthetic progestins (gestagens) originate
from excretion by humans and livestock. Synthetic progestins are used for contraception and …

Exposure to the contraceptive progestin, gestodene, alters reproductive behavior, arrests egg deposition, and masculinizes development in the fathead minnow …

TE Frankel, MT Meyer, DW Kolpin… - … science & technology, 2016 - ACS Publications
Endogenous progestogens and pharmaceutical progestins enter the environment through
wastewater treatment plant effluent and agricultural field runoff. Lab studies demonstrate …

Synthetic progestins in waste and surface waters: Concentrations, impacts and ecological risk

MJ Rocha, E Rocha - Toxics, 2022 - mdpi.com
Synthetic progestins (PGs) are a large family of hormones used in continuously growing
amounts in human and animal contraception and medicinal therapies. Because wastewater …

Wastewater treatment plant effluent alters pituitary gland gonadotropin mRNA levels in juvenile coho salmon (Oncorhynchus kisutch)

LB Harding, IR Schultz, DAM da Silva, GM Ylitalo… - Aquatic toxicology, 2016 - Elsevier
It is well known that endocrine disrupting compounds (EDCs) present in wastewater
treatment plant (WWTP) effluents interfere with reproduction in fish, including altered gonad …

Sources, concentrations, and exposure effects of environmental gestagens on fish and other aquatic wildlife, with an emphasis on reproduction

EF Orlando, LE Ellestad - General and comparative endocrinology, 2014 - Elsevier
Fish and other aquatic wildlife, including frogs, turtles, and alligators, have been used as
vertebrate sentinels for the effects of endocrine disrupting and other emerging chemicals of …

Several synthetic progestins with different potencies adversely affect reproduction of fish

TJ Runnalls, N Beresford, E Losty… - … science & technology, 2013 - ACS Publications
Synthetic progestins are widely used as a component in both contraceptives and in hormone
replacement therapy (HRT), both on their own and in combination with EE2. Their presence …

Effects of synthetic gestagens on fish reproduction

J Zeilinger, T Steger‐Hartmann, E Maser… - Environmental …, 2009 - Wiley Online Library
Although it is well known that estrogenic steroidal hormones are able to affect the sexual
development and reproduction of fish at low concentrations, no data on environmental …

The synthetic progestin megestrol acetate adversely affects zebrafish reproduction

J Han, Q Wang, X Wang, Y Li, S Wen, S Liu, G Ying… - Aquatic toxicology, 2014 - Elsevier
Synthetic progestins contaminate the aquatic ecosystem, and may cause adverse health
effects on aquatic organisms. Megestrol acetate (MTA) is present in the aquatic environment …

Progestins and Antiprogestins Affect Gene Expression in Early Development in Zebrafish (Danio rerio) at Environmental Concentrations

S Zucchi, S Castiglioni, K Fent - Environmental science & …, 2012 - ACS Publications
Progesterone (P4) and synthetic progestins (gestagens) from contraceptives and hormone
therapy occur in treated wastewater and surface water, and they may have adverse effects …