Aberrant amyloid-β peptide (Aβ) accumulation along with altered expression and function of
nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's …

Alzheimer's disease (AD) is one of the major disabling and lethal diseases for aged
individuals worldwide. To date, there are more than 10 hypotheses proposed for AD …

The nicotinic receptors (nAChRs), which play a critical role in cognitive function, are
impaired early in the course of Alzheimer's disease (AD). We have previously demonstrated …

Although there is still no known effective preventative treatment or cure for Alzheimer's
disease (AD), the development of new drugs that target pathological features that appear …

Alzheimer's Disease (AD) is the most common of the senile dementias, the prevalence of
which is increasing rapidly, with a projected 14 million affected worldwide by 2025. The …

The decades‐old cholinergic hypothesis of Alzheimer's disease (AD) led to clinical testing
and FDA approval of acetylcholinesterase inhibitor drugs. Subsequently, the α7 nicotinic …

Deterioration of the cortical cholinergic system is a leading neurochemical feature of
Alzheimer's Disease (AD). This review summarizes evidence that the homomeric α7 …

Alzheimer's disease (AD) is a neurodegenerative condition characterized by increased
accumulation of Aβ and degeneration of cholinergic signaling between basal forebrain and …

Background β-amyloid (Aβ) accumulation is described as a hallmark of Alzheimer's disease
(AD). Aβ perturbs a number of synaptic components including nicotinic acetylcholine …

The accumulation of amyloid-beta peptide (Aβ) and the failure of cholinergic transmission
are key players in Alzheimer's disease (AD). However, in the healthy brain, Aβ contributes to …