Chromosomal rearrangements are thought to play a role in speciation, adaptation and
evolution. The effects of chromosomal rearrangements on gene expression have been …

Comparative genomics is an important and expanding field of research, and the genome-
wide comparison of the chromosome constitution of different species makes a major …

This review describes my personal reflections on the development of whole chromosome
painting using fluorescence in situ hybridization and how my laboratory applied the …

Advances in synthetic biology methods to assemble and edit DNA are enabling genome
engineering at a previously impracticable scale and scope. The synthesis of the …

As biotechnology advances, there is an increasing need to develop new technologies that
may assist in more precise genetic engineering manipulations. Whether a placement of …

Chromosomal rearrangements have been instrumental in genetic studies in Drosophila.
Visibly marked deficiencies (deletions) are used in mapping studies and region-specific …

Historical analysis of studying chromosome changes in evolution allows better
understanding of the current level of research in this area. Reorganizations of the genetic …

Species differ in the number and shape of chromosomes as well as in anatomy, physiology
and genetics. Chromosome rearrangement may play an important role in the evolution of …

Chromosomal rearrangements occur frequently in humans and can be disease-associated
or phenotypically neutral. Recent technological advances have led to the discovery of copy …

Recent progress in mammalian genomics raises enormous expectations for rapid advances
in global understanding of the genetic program. The Human Genome Sequencing Project …