Various obstacles impede the chemotherapy efficiency of glioma in clinic, such as blood
brain barrier (BBB) and blood brain tumor barrier (BBTB). Ligand-mediated polymeric …

The effective chemotherapy for glioblastoma multiform (GBM) requires a nanomedicine that
can both penetrate the blood-brain barrier (BBB) and target the glioma cells subsequently. In …

Current therapeutic strategies against glioblastoma multiforme (GBM) are futile mainly
because of the poor access of drugs into malignant tissues, which is hindered by the tight …

Background The safe and efficient delivery of chemotherapeutic agents is critical to glioma
therapy. However, chemotherapy for glioma is extremely challenging because the blood …

Glioma is regarded as the deadliest and most common brain tumor because of the extremely
difficult surgical excision ascribed from its invasive nature. In addition, the natural blood …

Low permeability across the blood–brain tumor barrier (BTB) and poor penetration into the
glioma parenchyma represent key obstacles for anti-glioblastoma drug delivery. In this …

The use of glioblastoma-targeted drug delivery system facilitates efficient delivery of
chemotherapeutic agents to malignant gliomas in the central nervous system while …

Glioma features high fatality rate and short survival time of patients due to its fast growth
speed and high invasiveness, hence timely treatment of early‐stage glioma is extremely …

Effective treatment of glioma and other central nervous system (CNS) diseases is hindered
by the presence of the blood–brain barrier (BBB). A novel nano-delivery vehicle system …

Glioblastoma multiforme (GBM) is the most common and aggressive primary central nervous
system (CNS) tumor with a short survival time. The failure of chemotherapy is ascribed to the …