This review reconsiders how the Th1/Th2 paradigm can be applied to Th1-mediated
autoimmune disease. Although there is evidence that autoimmune diseases such as …

In both mice and humans, functionally distinct helper T (Th)-cell subsets, known as Th1 and
Th2 cells, are characterized by the patterns of cytokines they produce. These two polarized …

In the past few years, considerable evidence has accumulated to suggest the existence of
functionally polarized responses by the CD4+ T helper (Th)—and the CD8+ T cytotoxic (Tc) …

Many autoimmune diseases are caused by autopathogenic Th1 cells. Because in vitro Th1
and Th2 cells cross-regulate each other, it is likely that the induction of self-antigen-specific …

CD4 helper T cells can be divided into Th1 and Th2 subsets based upon the cytokines they
produce. Th1 and Th2 cells have been found to be mutually antagonistic, leading to either …

Differentiated T cells produce a restricted set of lymphokines, allowing their subdivision into
two major subsets: Th1 and Th2 cells. This has lead to a new paradigm for …

The study of autoimmune disease in the context of T-helper type 1 (Th1) and T-helper type 2
(Th2) CD4+ T-cell responses demonstrates that the relative contribution of either T-cell type …

Evidence is accumulating to suggest the existence of polarized human T-cell responses,
reminiscent of TH 1 and TH 2 subsets described for mouse T cells. Human TH 1 cells …

By virtue of their functional antagonism, Thl cells or cells producing the same cytokines as
Thl cells may behave as' suppressor cells' with respect to Th2 cells and vice versa. An …

It is now clear that CD4+ helper T cells (Th) include at least two different subsets called Thl
and Th2. These subsets have been characterized in mice [1], rats [2] and humans [3]. They …