The role of methyl-binding proteins in chromatin organization and epigenome maintenance
A Fournier, N Sasai, M Nakao… - Briefings in functional …, 2012 - academic.oup.com
Methylated DNA can be specifically recognized by a set of proteins called methyl-CpG-
binding proteins (MBPs), which belong to three different structural families in mammals: the …
binding proteins (MBPs), which belong to three different structural families in mammals: the …
On how mammalian transcription factors recognize methylated DNA
BA Buck-Koehntop, PA Defossez - Epigenetics, 2013 - Taylor & Francis
DNA methylation is an epigenetic mark that is essential for the development of mammals; it
is frequently altered in diseases ranging from cancer to psychiatric disorders. The presence …
is frequently altered in diseases ranging from cancer to psychiatric disorders. The presence …
[PDF][PDF] Many paths to one goal? The proteins that recognize methylated DNA in eukaryotes
N Sasai, PA Defossez - International Journal of Developmental …, 2009 - researchgate.net
ABSTRACT DNA methylation is an epigenetically inherited chemical modification that is
associated with transcriptional silencing and is essential for mammalian development. The …
associated with transcriptional silencing and is essential for mammalian development. The …
Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer
OJ Sansom, K Maddison, AR Clarke - Nature clinical practice Oncology, 2007 - nature.com
The methyl-CpG-binding domain (MBD) proteins' read'and interpret the methylation moieties
on DNA, and thus are critical mediators of many epigenetic processes. Currently, the MBD …
on DNA, and thus are critical mediators of many epigenetic processes. Currently, the MBD …
Biological functions of methyl-CpG-binding proteins
PA Defossez, I Stancheva - Progress in molecular biology and translational …, 2011 - Elsevier
DNA methylation is a stable epigenetic mark in plant and vertebrate genomes; it is
implicated in regulation of higher order chromatin structure, maintenance of genome …
implicated in regulation of higher order chromatin structure, maintenance of genome …
Methyl-CpG-binding domain proteins: readers of the epigenome
How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …
Preferential binding of the methyl-CpG binding domain protein 2 at methylated transcriptional start site regions
A Chatagnon, L Perriaud, N Nazaret, S Croze… - Epigenetics, 2011 - Taylor & Francis
Methyl-CpG Binding Domain (MBD) proteins are thought to be key molecules in the
interpretation of DNA methylation signals leading to gene silencing through recruitment of …
interpretation of DNA methylation signals leading to gene silencing through recruitment of …
Methyl CpG binding proteins: coupling chromatin architecture to gene regulation
PA Wade - Oncogene, 2001 - nature.com
A correlation between DNA methylation and transcriptional silencing has existed for many
years. Recently, substantial progress has been reported in the search for proteins that …
years. Recently, substantial progress has been reported in the search for proteins that …
[HTML][HTML] Methylation-dependent and-independent genomic targeting principles of the MBD protein family
To gain insight into the cellular readout of DNA methylation, we established a strategy for
systematically profiling the genome-wide distribution of chromatin-interacting factors. This …
systematically profiling the genome-wide distribution of chromatin-interacting factors. This …
Transcription factors as readers and effectors of DNA methylation
Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …
base-pair resolution under various physiological conditions. Many aberrant or differentially …