Clinically, cardiac dysfunction is a key component of sepsis-induced multi-organ failure.
Mitochondria are essential for cardiomyocyte homeostasis, as disruption of mitochondrial …

Sepsis‐induced cardiac dysfunction remains one of the major causes of death in intensive
care units. Overwhelmed inflammatory response and unrestrained cell death play critical …

Background—Cardiac dysfunction with sepsis is associated with both inflammation and
reduced fatty acid oxidation. We hypothesized that energy deprivation accounts for sepsis …

Rationale: Peroxisome proliferator-activated receptors (PPARs)(α, γ, and δ/β) are nuclear
hormone receptors and ligand-activated transcription factors that serve as key determinants …

Children with sepsis and multisystem organ failure have downregulated leukocyte gene
expression of peroxisome proliferator-activated receptor-α (PPARα), a nuclear hormone …

It is well documented that PPARα and PPARβ/δ share overlapping functions in regulating
myocardial lipid metabolism. However, previous studies demonstrated that cardiomyocyte …

Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is an essential transcription factor
in myocardial metabolism. This study aims to investigate the effects of PPARβ/δ activation in …

Background Sepsis-induced myocardial dysfunction is associated with worse clinical
outcomes and high mortality, but no effective therapeutic intervention has been explored …

Background/Aims: Morphological and biochemical maladaptation of cardiomyocytes are
associated with mitochondrial dysfunction and dysregulation in hypertrophic conditions …

Objectives: Peroxisome proliferator–activated receptor-α is significantly down-regulated in
circulating leukocytes from children with sepsis. Peroxisome proliferator–activated receptor …