Receptors used by natural killer (NK) cells to mediate natural cytotoxicity are poorly defined,
although it is now clear that a number of adhesion molecules can serve this function. CD38 …

CD38, a surface glycoprotein of unrestricted lineage, is an ectoenzyme (adenosine
diphosphate [ADP] ribosyl cyclase/cyclic ADP-ribose hydrolase) that regulates cytoplasmic …

Human CD38 is a signal transduction molecule, and, concurrently, an ectoenzyme
catalyzing the synthesis and degradation of cyclic ADP-ribose (cADPR), a potent Ca2+ …

The mitogen‐activated protein kinase (MAPK) p38 modulates a variety of cellular functions,
including proliferation, differentiation and cell death. However, we report here a novel …

Natural killer (NK) cells are physiologically involved in the immune response against
viruses, intracellular bacteria, and parasites as well as against malignant diseases. In …

Activated human natural killer (NK) cells undergo rapid apoptotic cell death after ligand
binding to the Fc receptor (CD16). We examined whether human NK cells die after …

Protection against cellular stress from various sources, such as nutritional, physical,
pathogenic, or oncogenic, results in the induction of both intrinsic and extrinsic cellular …

CD44 is a cytotoxic triggering molecule on activated, but not fresh natural killer (NK) cells. In
the current study, metabolic pathways used in CD44-directed lysis (CD44DL) were …

It has been previously shown that the subset of human natural killer (NK) cells which
express CD8 in a homodimeric α/α form are more cytotoxic than their CD8–counterparts but …

Abstract Interferon-γ (IFN-γ) is critical for an effective innate immune response against
infection. A combination of interleukins (ILs) derived from activated T cells (IL-2) and …