B lymphocytes are required for the pathogenesis of autoimmune diabetes in NOD mice.
Previous studies established that a lymphopenic transitional (TR) B cell compartment …

Targeting the BAFF/APRIL system has shown to be effective in preventing T‐cell dependent
autoimmune disease in the NOD mouse, a spontaneous model of type 1 diabetes. In this …

In NOD mice and also likely humans, B lymphocytes play an important role as APC-
expanding autoreactive T cell responses ultimately causing type 1 diabetes (T1D). Currently …

Obesity-associated insulin resistance, a common precursor of type 2 diabetes, is
characterized by chronic inflammation of tissues, including visceral adipose tissue (VAT) …

OBJECTIVE Tumor necrosis factor ligand family members B-cell–activating factor (BAFF)
and a proliferation-inducing ligand (APRIL) can exert powerful effects on B-cell activation …

Background. Immunologic rejection is a major barrier to successful long-term outcomes in
clinical transplantation. The importance of B lymphocytes—and their secretory products …

B cell activating factor of the tumor necrosis factor family (BAFF or BLyS) is a critical factor for
B cell survival and maturation. BAFF-transgenic (BAFF-Tg) mice develop autoimmunity that …

B cell-activating factor of the TNF family (BAFF) is an essential B cell survival factor.
However, high levels of BAFF promote systemic lupus erythematosus (SLE) in mice and …

Increased levels of B lymphocyte stimulator (BLyS) are associated with systemic
autoimmunity in animal models of spontaneous autoimmune disease, and transgenic …

Mice overexpressing B cell activating factor of the TNF family (BAFF) develop systemic
autoimmunity characterized by class-switched anti-nuclear Abs. Transmembrane activator …